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BME Seminar Series: Prashant Mali, PhD

March 28 @ 12:00 PM 1:00 PM

Programmable tools for DNA, RNA and protein targeting: new approaches, new challenges

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Prashant Mali, PhD
Associate Professor of Bioengineering
University of California San Diego

Abstract
Per the central dogma, one can in principle target a gene at the DNA, RNA or protein levels. Targeting at the DNA level is permanent and from a therapeutic standpoint potentially curative, but targeting at the RNA and protein levels, while transient, offers advantages in tunability and reversibility. In this seminar, I will describe some of our recent efforts on these fronts, and in particular our work on development of CRISPRs, ADARs and protein-protein interaction interfering peptides as programmable tools for enabling DNA, RNA and protein targeting respectively.

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