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Prashant Mali, PhDAssociate Professor of BioengineeringUniversity of California San Diego
AbstractPer the central dogma, one can in principle target a gene at the DNA, RNA or protein levels. Targeting at the DNA level is permanent and from a therapeutic standpoint potentially curative, but targeting at the RNA and protein levels, while transient, offers advantages in tunability and reversibility. In this seminar, I will describe some of our recent efforts on these fronts, and in particular our work on development of CRISPRs, ADARs and protein-protein interaction interfering peptides as programmable tools for enabling DNA, RNA and protein targeting respectively.
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