Skip to main content
Loading Events

« All Events

  • This event has passed.

BME Seminar Series: Sheena Kerr, PhD

October 17 @ 12:00 PM 1:00 PM

Sheena Kerr

Engineering microphysiological systems of the tumor microenvironment

Sheena Kerr, PhD
Scientist
Microtechnology, Medicine, and Biology Lab
UW-Madison

Microphysiological systems (MPS) can bridge the gap between traditional 2-dimensional in vitro platforms and in vivo models. These engineered models can recapitulate both the tissue architecture and multicellular crosstalk of the biological niche, which can have a profound effect on cellular phenotype and function. In this talk, I will detail our work on creating MPS that represent the tumor microenvironment (TME), the complex mix of stromal cells, immune cells and vasculature that surrounds the tumor. Specifically, I will describe how we use microfluidic devices to recreate the TME, mimicking the solid tumor, vasculature and stroma and demonstrate how we can use these MPS to elucidate the biology of metastasis, investigate critically understudied sites such as bone metastases and work towards creation of patient-specific models that could inform clinical decision making. Additionally, I will also discuss a microscale platform for multiplexed analysis of low volume blood samples.

Print PDF

1550 Engineering Drive
Madison, WI 53706 United States
+ Google Map