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Venkat Keshav Chivukula, PhDAssistant Professor, Department of Biomedical EngineeringFlorida Institute of Technology
Corrinne Bahr Memorial Lecture
Increasing prevalence of cardiovascular disease worldwide has led to growing dependence on medical device therapies such as ventricular assist devices, mechanical heart valves and other blood-contacting devices. However, the success of a medical device can be severely hindered by complications such as emboli formation/thrombosis leading to device failure and other devastating events such as stroke and myocardial infarction. Thrombus formation results from both response to foreign materials, as well as non-physiological blood flow introduced by these devices. Elucidating the complex interplay between hemodynamic stimuli and biological response is essential for mitigating these issues and for improving biocompatibility of medical device therapy. Blood as a fluid is truly unique, comprising of red blood cells, white blood cells and platelets suspended in plasma. Thus, the diverse and complex behavior of blood as a particle-laden fluid operating under various spatio-temporal interdependencies presents a fascinating and challenging problem to analyze. In this seminar, I will describe some of the approaches that we utilize at various scales (micro, meso and macro) to investigate the hemodynamics of surgical optimization and designing patient management strategies for cardiovascular disease therapy. Specifically, I will focus on clinically-relevant applications such as thrombosis and heart failure therapies (ventricular assist devices). I will describe the ongoing projects in my lab to incorporate virtual surgery, hemodynamic optimization and multi-scale approaches into predictive hemodynamic modeling to understand, detect, diagnose and treat cardiovascular disease.