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Wei-Chuan Shih, PhDCullen Professor; Electrical & Computer EngineeringUniversity of Houston
AbstractLight matter interactions can provide rich compositional information from various samples in a non-invasive fashion. Our laboratory has developed opto-analytical spectroscopy, imaging, and sensing technologies to address unmet needs across various biological length scale including molecules, vesicles, cells, and tissue. The central innovations in our work include nano and micro engineering, imaging and spectroscopy instrumentation, and machine learning techniques. I will discuss some examples in this seminar. Harnessing localized surface plasmons (LSP) and coupling modes, we have engineered enhanced light-matter interactions near nanostructured surfaces for molecular sensing, catalysis, photothermal manipulation, and superresolution imaging. We have also developed an “inkjet-printing” method for fabricating flexible polymers lenses suitable for smartphone microscopy with applications in biomedical imaging, environmental sensing, STEM education, and citizen science. Finally, I will briefly discuss a non-invasive glucose sensing technology based on Raman spectroscopy and machine learning.