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CBE Spring Seminar Series featuring Marianthi Ierapetritou

April 5 @ 4:00 PM 5:00 PM

Professor
Department of Chemical and Biomolecular Engineering
University of Delaware

photo of Prof. Ierapetritou

Can we make drugs faster, cheaper, and better? Yes, we can: Process Systems Engineering Approaches to Advance Pharmaceutical Manufacturing 

 The global pharmaceutical industry has been on an growing trend since the early 2000s, enhancing life expectancies and healthcare around the world. As a result, the overall pharmaceutical revenue and sales have steadily been increasing, reaching $1.27 trillion dollars in 2020, 25% of which is allocated to research and development. Regulated by government agencies like U.S. Food and Drug Administration (FDA) and European Medicine Agency, drug industry has been traditionally resisted to changes especially related to drug production/manufacturing a trend that has been revised over the last decade to enable more efficient and agile manufacturing technologies and to ensure product quality eliminating drug shortages. 

Recent developments towards Industry 4.0 have led to generation of large volume of data for the entire manufacturing cycle that could lead to complete transformation of drug manufacturing. However, what is needed is the development of efficient approaches that are capable to efficiently extract the available information, visualize the state of the system, and help in the decision making. 

Process Systems Engineering tools can play a critical role in this transformation with the development of new modeling frameworks and algorithmic solution approaches. The major challenges to achieve this goal, and highlights of the work that has been performed in our lab in the last 10 years to address these problems will be highlighted in the talk. 

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