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DTSTART;TZID=America/Chicago:20260302T120000
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DTSTAMP:20260405T064635
CREATED:20260121T162113Z
LAST-MODIFIED:20260217T010320Z
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SUMMARY:BME Seminar Series: Ankur Singh\, PhD
DESCRIPTION:Revolutionizing Immunotherapy: Bioengineered Immune Organs and Nanoscale Technologies\n\n\n\n\n\n\n\nAnkur Singh\, PhDCarl Ring Family ProfessorGeorge W. Woodruff School of Mechanical EngineeringWallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory MedicineDirector\, Center for Immunoengineering at Georgia TechGeorgia Institute of Technology \n\n\n\nAbstract:The human immune system is a complex and vital defense network\, yet its dysfunction underlies many diseases. Developing effective vaccines\, immunotherapies\, and cell therapies for infections\, cancer\, inflammation\, and age-related conditions requires a deep understanding of how immune cells develop and activate in primary\, secondary\, and tertiary lymphoid organs. Traditionally limited to in vivo studies and 2D in vitro models\, which lack full physiological relevance\, research is now advancing with engineered human ex vivo immune organoids. These synthetic tissues mimic the structure and function of natural immune organs\, enabling precise control of cellular interactions. My lab focuses on developing such organoids by combining engineered materials with donor-derived immune cells to generate antibody-secreting cells and assess immunogenicity. We are also developing advanced organ-on-a-chip systems with full immunocompetence for use in infection\, inflammation\, oncology\, and drug development\, thereby opening new possibilities for groundbreaking therapeutic discoveries. Complementing tissue-scale engineering\, I will introduce nanoengineered wire platforms that program naïve T cells without pre-activation through localized delivery of regulatory microRNAs. These nanoscale interfaces rewire T-cell fitness\, proliferation\, and differentiation\, thereby enhancing protective responses and improving the design of adoptive cell therapies. These approaches establish a multi-scale framework for controlling immune cell fate and function. I will conclude by outlining a cohesive\, forward-looking vision for Biomedical Engineering\, highlighting opportunities for advancing research excellence\, educational innovation\, and translational impact within a strategic framework. \n\n\n\nPrint PDF
URL:https://engineering.wisc.edu/event/bme-seminar-series-6/
LOCATION:1003 (Tong Auditorium) Engineering Centers Building\, 1550 Engineering Drive\, Madison\, WI\, 53706\, United States
CATEGORIES:Biomedical Engineering,Seminar
ATTACH;FMTTYPE=image/jpeg:https://engineering.wisc.edu/wp-content/uploads/2024/11/Seminar-Graphic-Fall2024-1.avif
ORGANIZER;CN="Department of Biomedical Engineering":MAILTO:bmehelp@bme.wisc.edu
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BEGIN:VEVENT
DTSTART;TZID=America/Chicago:20260316T120000
DTEND;TZID=America/Chicago:20260316T130000
DTSTAMP:20260405T064635
CREATED:20260121T162225Z
LAST-MODIFIED:20260309T194054Z
UID:10001436-1773662400-1773666000@engineering.wisc.edu
SUMMARY:BME Seminar Series: Wan-Ju Li\, PhD\, FIOR
DESCRIPTION:From Development to Repair: Using Skeletal Development Principles to Advance Stem Cell-Mediated Cartilage Regeneration\n\n\n\n\n\n\n\nWan-Ju Li\, PhD\, FIORAssociate ProfessorDepartment of Orthopedics and RehabilitationUniversity of Wisconsin-Madison \n\n\n\nAbstract:Why does cartilage regeneration still fall short despite major progress in stem cell engineering? In this seminar\, I will argue that one important reason is that cartilage repair strategies are often developed without fully accounting for the developmental programs that shape cartilage formation in vivo. I will present our lab’s recent work showing that developmental origin strongly influences the identity and regenerative potential of human iPSC-derived chondrocytes. \n\n\n\nUsing isogenic differentiation models\, we compared mesoderm-derived and neural crest-derived chondrocytes and found that neural crest-derived chondrocytes more closely resemble native articular chondrocytes and perform better in cartilage repair settings. Building on these findings\, I will also discuss our efforts to develop a stepwise induction strategy for generating chondrocytes from human iPSC-derived neural crest cells in a more controlled and efficient manner. \n\n\n\nTogether\, these studies support a broader message that developmental biology is not simply background knowledge for regenerative medicine\, but a practical framework for selecting better cell sources\, asking more precise biological questions\, and overcoming major barriers in the field. \n\n\n\nPrint PDF
URL:https://engineering.wisc.edu/event/bme-seminar-series-7/
LOCATION:1003 (Tong Auditorium) Engineering Centers Building\, 1550 Engineering Drive\, Madison\, WI\, 53706\, United States
CATEGORIES:Biomedical Engineering,Seminar
ATTACH;FMTTYPE=image/jpeg:https://engineering.wisc.edu/wp-content/uploads/2024/11/Seminar-Graphic-Fall2024-1.avif
ORGANIZER;CN="Department of Biomedical Engineering":MAILTO:bmehelp@bme.wisc.edu
END:VEVENT
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DTSTART;TZID=America/Chicago:20260323T120000
DTEND;TZID=America/Chicago:20260323T130000
DTSTAMP:20260405T064635
CREATED:20260121T162320Z
LAST-MODIFIED:20260316T202428Z
UID:10001437-1774267200-1774270800@engineering.wisc.edu
SUMMARY:BME Seminar Series: Christopher Konop\, PhD
DESCRIPTION:How Serious Fun (and Mild Panic) Led Me from Academia to Venture Innovation\n\n\n\n\n\n\n\nChristopher Konop\, PhDInnovation and Commercialization SpecialistIsthmus ProjectUW Health \n\n\n\nAbstract:Most scientific careers don’t follow a straight line—and mine certainly didn’t. I’ve moved from academia to startups\, consulting\, and eventually venture innovation. I’ll share a few brief stories from building WiSolve\, stepping into life‑science consulting\, and helping develop the Isthmus Project to spark conversation and address the career-development questions that are top of mind for graduate students and postdocs. I’m glad to offer practical insights\, hot tips\, and lessons learned along the way. Spoiler: none of it would have been possible without great mentors and a generous network. \n\n\n\nPrint PDF
URL:https://engineering.wisc.edu/event/bme-seminar-series-8/
LOCATION:1003 (Tong Auditorium) Engineering Centers Building\, 1550 Engineering Drive\, Madison\, WI\, 53706\, United States
CATEGORIES:Biomedical Engineering,Seminar
ATTACH;FMTTYPE=image/jpeg:https://engineering.wisc.edu/wp-content/uploads/2024/11/Seminar-Graphic-Fall2024-1.avif
ORGANIZER;CN="Department of Biomedical Engineering":MAILTO:bmehelp@bme.wisc.edu
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