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SUMMARY:BME Seminar Series: Ankur Singh\, PhD
DESCRIPTION:Revolutionizing Immunotherapy: Bioengineered Immune Organs and Nanoscale Technologies\n\n\n\n\n\n\n\nAnkur Singh\, PhDCarl Ring Family ProfessorGeorge W. Woodruff School of Mechanical EngineeringWallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory MedicineDirector\, Center for Immunoengineering at Georgia TechGeorgia Institute of Technology \n\n\n\nAbstract:The human immune system is a complex and vital defense network\, yet its dysfunction underlies many diseases. Developing effective vaccines\, immunotherapies\, and cell therapies for infections\, cancer\, inflammation\, and age-related conditions requires a deep understanding of how immune cells develop and activate in primary\, secondary\, and tertiary lymphoid organs. Traditionally limited to in vivo studies and 2D in vitro models\, which lack full physiological relevance\, research is now advancing with engineered human ex vivo immune organoids. These synthetic tissues mimic the structure and function of natural immune organs\, enabling precise control of cellular interactions. My lab focuses on developing such organoids by combining engineered materials with donor-derived immune cells to generate antibody-secreting cells and assess immunogenicity. We are also developing advanced organ-on-a-chip systems with full immunocompetence for use in infection\, inflammation\, oncology\, and drug development\, thereby opening new possibilities for groundbreaking therapeutic discoveries. Complementing tissue-scale engineering\, I will introduce nanoengineered wire platforms that program naïve T cells without pre-activation through localized delivery of regulatory microRNAs. These nanoscale interfaces rewire T-cell fitness\, proliferation\, and differentiation\, thereby enhancing protective responses and improving the design of adoptive cell therapies. These approaches establish a multi-scale framework for controlling immune cell fate and function. I will conclude by outlining a cohesive\, forward-looking vision for Biomedical Engineering\, highlighting opportunities for advancing research excellence\, educational innovation\, and translational impact within a strategic framework. \n\n\n\nPrint PDF
URL:https://engineering.wisc.edu/event/bme-seminar-series-6/
LOCATION:1003 (Tong Auditorium) Engineering Centers Building\, 1550 Engineering Drive\, Madison\, WI\, 53706\, United States
CATEGORIES:Biomedical Engineering,Seminar
ATTACH;FMTTYPE=image/jpeg:https://engineering.wisc.edu/wp-content/uploads/2024/11/Seminar-Graphic-Fall2024-1.avif
ORGANIZER;CN="Department of Biomedical Engineering":MAILTO:bmehelp@bme.wisc.edu
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