BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//College of Engineering - University of Wisconsin-Madison - ECPv6.15.18//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-ORIGINAL-URL:https://engineering.wisc.edu
X-WR-CALDESC:Events for College of Engineering - University of Wisconsin-Madison
REFRESH-INTERVAL;VALUE=DURATION:PT1H
X-Robots-Tag:noindex
X-PUBLISHED-TTL:PT1H
BEGIN:VTIMEZONE
TZID:America/Chicago
BEGIN:DAYLIGHT
TZOFFSETFROM:-0600
TZOFFSETTO:-0500
TZNAME:CDT
DTSTART:20250309T080000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0500
TZOFFSETTO:-0600
TZNAME:CST
DTSTART:20251102T070000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:-0600
TZOFFSETTO:-0500
TZNAME:CDT
DTSTART:20260308T080000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0500
TZOFFSETTO:-0600
TZNAME:CST
DTSTART:20261101T070000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:-0600
TZOFFSETTO:-0500
TZNAME:CDT
DTSTART:20270314T080000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0500
TZOFFSETTO:-0600
TZNAME:CST
DTSTART:20271107T070000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=America/Chicago:20260316T120000
DTEND;TZID=America/Chicago:20260316T130000
DTSTAMP:20260407T043934
CREATED:20260121T162225Z
LAST-MODIFIED:20260309T194054Z
UID:10001436-1773662400-1773666000@engineering.wisc.edu
SUMMARY:BME Seminar Series: Wan-Ju Li\, PhD\, FIOR
DESCRIPTION:From Development to Repair: Using Skeletal Development Principles to Advance Stem Cell-Mediated Cartilage Regeneration\n\n\n\n\n\n\n\nWan-Ju Li\, PhD\, FIORAssociate ProfessorDepartment of Orthopedics and RehabilitationUniversity of Wisconsin-Madison \n\n\n\nAbstract:Why does cartilage regeneration still fall short despite major progress in stem cell engineering? In this seminar\, I will argue that one important reason is that cartilage repair strategies are often developed without fully accounting for the developmental programs that shape cartilage formation in vivo. I will present our lab’s recent work showing that developmental origin strongly influences the identity and regenerative potential of human iPSC-derived chondrocytes. \n\n\n\nUsing isogenic differentiation models\, we compared mesoderm-derived and neural crest-derived chondrocytes and found that neural crest-derived chondrocytes more closely resemble native articular chondrocytes and perform better in cartilage repair settings. Building on these findings\, I will also discuss our efforts to develop a stepwise induction strategy for generating chondrocytes from human iPSC-derived neural crest cells in a more controlled and efficient manner. \n\n\n\nTogether\, these studies support a broader message that developmental biology is not simply background knowledge for regenerative medicine\, but a practical framework for selecting better cell sources\, asking more precise biological questions\, and overcoming major barriers in the field. \n\n\n\nPrint PDF
URL:https://engineering.wisc.edu/event/bme-seminar-series-7/
LOCATION:1003 (Tong Auditorium) Engineering Centers Building\, 1550 Engineering Drive\, Madison\, WI\, 53706\, United States
CATEGORIES:Biomedical Engineering,Seminar
ATTACH;FMTTYPE=image/jpeg:https://engineering.wisc.edu/wp-content/uploads/2024/11/Seminar-Graphic-Fall2024-1.avif
ORGANIZER;CN="Department of Biomedical Engineering":MAILTO:bmehelp@bme.wisc.edu
END:VEVENT
END:VCALENDAR