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SUMMARY:BME Seminar Series: Daniel Gallego-Perez\, PhD
DESCRIPTION:Nanotransfection-driven gene and cell therapies\n\n\n\n\n\n\n\nDaniel Gallego-Perez\, PhDEdgar C. Hendrickson Chair in Biomedical EngineeringProfessor\, Surgery GeneralThe Ohio State University \n\n\n\nAbstract:Gene and engineered cell therapies hold transformative potential for treating a wide range of conditions. However\, current approaches face significant practical and translational challenges\, including a heavy reliance on viral vectors and high variability\, which often result in inefficient or unpredictable outcomes. To address these limitations\, we developed a novel nanotechnology-based approach that enables deterministic cell (in vitro) or tissue nano-transfection (TNT) (in vivo) without the need for viral vectors. These platform technologies offer a minimally disruptive and non-viral solution\, making them particularly suited for complex disease systems such as neurodegenerative conditions and metabolic disorders. Nano-transfection chips were manufactured from silicon or polymeric track etched membranes using cleanroom-based approaches\, as described previously. These chips were then used to nanotransfect skin cells\, in vitro or in vivo\, with pro-vasculogenic or pro-adipogenic gene cocktails\, which were then evaluated (for their therapeutic potential) in different murine models of neurodegenerative conditions\, including ischemic stroke\, and Alzheimer’s disease (AD)\, as well as models of metabolic dysfunction. Different molecular\, histological\, and functional outcomes studies were conducted to assess the extent to which these therapies mitigated disease burden in each model. In murine models of ischemic stroke\, nanotransfected fibroblasts improved brain vascularization\, perfusion\, as well as neuroprotection and neuroregeneration in the motor cortex\, which led to improved motor function. In murine models of AD\, nanotransfected fibroblasts led to improved brain vascularization\, perfusion\, and reduced amyloid beta load. This also correlated with improved memory and cognitive function. Finally\, in murine models of metabolic dysfunction\, TNT-treated skin cells were successfully coopted to partially fulfill brown adipogenic functions\, which led to improved weight control and cardiometabolic function. Overall\, these findings highlight the potential of cell and tissue nano-transfection to drive therapeutic processes for restoring damaged or diseased tissue structure and function\, paving the way for innovative treatments across diverse pathological conditions. \n\n\n\nPrint PDF
URL:https://engineering.wisc.edu/event/bme-seminar-series-daniel-gallego-perez-phd/
LOCATION:1003 (Tong Auditorium) Engineering Centers Building\, 1550 Engineering Drive\, Madison\, WI\, 53706\, United States
CATEGORIES:Biomedical Engineering,Seminar
ATTACH;FMTTYPE=image/jpeg:https://engineering.wisc.edu/wp-content/uploads/2024/11/Seminar-Graphic-Fall2024-1.avif
ORGANIZER;CN="Department of Biomedical Engineering":MAILTO:bmehelp@bme.wisc.edu
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DTSTART;TZID=America/Chicago:20250421T120000
DTEND;TZID=America/Chicago:20250421T130000
DTSTAMP:20260405T223632
CREATED:20250204T172623Z
LAST-MODIFIED:20250407T164208Z
UID:10001148-1745236800-1745240400@engineering.wisc.edu
SUMMARY:BME Seminar Series: Alan Jassanof\, PhD
DESCRIPTION:Analyzing Brain-Wide Function Using New Molecular Imaging Tools\n\n\n\n\n\n\n\nAlan Jasanoff\, PhDProfessor of Biological Engineering and Brain and Cognitive SciencesMassachusetts Institute of Technology \n\n\n\nAbstract:Behavior and cognition depend on the integrated action of neural structures and populations distributed throughout the brain. Deciphering mechanisms by which this takes this place is both a tremendous scientific problem and a major engineering challenge\, because of the need to establish suitable measurement technologies. We are creating a set of molecular imaging tools that enable multiregional neural processing to be studied at a brain-wide scale in rodents and nonhuman primates. Here we will describe how a novel genetically encoded activity reporter we have engineered enables information flow in virally labeled neural circuitry to be monitored by fMRI. Using the reporter to perform functional imaging of synaptically defined cell populations in the rat somatosensory system\, we show how activity is transformed within brain regions to yield characteristics specific to distinct output projections. We also show how this approach enables regional activity phenomena to be modeled in terms of inputs\, in a paradigm that we are extending to address circuit-level origins of functional specialization in marmoset brains. In the second part of the talk\, we will discuss how some of our MRI tools now enable the detection of optical reporters in deep neural tissue. We use novel imaging probes to detect luminescent proteins\, yielding a hybrid optical/MRI noninvasive imaging modality that surpasses limitations of conventional methods. This work demonstrates the possibility of investigating diverse brain-wide processing phenomena using advanced molecular neuroimaging methods. \n\n\n\nPrint PDF
URL:https://engineering.wisc.edu/event/bme-seminar-series-alan-jassanof-phd/
LOCATION:1003 (Tong Auditorium) Engineering Centers Building\, 1550 Engineering Drive\, Madison\, WI\, 53706\, United States
CATEGORIES:Biomedical Engineering,Seminar
ATTACH;FMTTYPE=image/jpeg:https://engineering.wisc.edu/wp-content/uploads/2024/11/Seminar-Graphic-Fall2024-1.avif
ORGANIZER;CN="Department of Biomedical Engineering":MAILTO:bmehelp@bme.wisc.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Chicago:20250428T120000
DTEND;TZID=America/Chicago:20250428T130000
DTSTAMP:20260405T223632
CREATED:20250204T172651Z
LAST-MODIFIED:20250407T164436Z
UID:10001149-1745841600-1745845200@engineering.wisc.edu
SUMMARY:BME Seminar Series: Jessica Wagenseil\, PhD
DESCRIPTION:Biomechanics of Thoracic Aortic Aneurysms\n\n\n\n\n\n\n\nJessica Wagenseil\, DScProfessor\, Mechanical Engineering and Materials ScienceVice Dean for Faculty AdvancementMcKelvey School of EngineeringWashington University \n\n\n\nAbstract:Thoracic aortic aneurysms are a dilation of the aortic wall that can be asymptomatic for many years until they dissect or rupture. Dissection or rupture is associated with a high mortality rate. Surgical replacement is the current treatment standard and is performed when the aortic aneurysm reaches a specified size or growth rate. However\, many aortic aneurysms fail before reaching these thresholds and many pass the thresholds without failing. We are interested in predicting how the aneurysm will grow\, remodel\, and fail in response to mechanical stimuli using mouse models of human aneurysmal disease. Data will be presented from our work on biomechanical metrics associated with aneurysms\, correlations between mechanical changes and biochemical signaling\, growth and remodeling predictions of aneurysm progression\, fluid-solid structure interaction modeling of aneurysm biomechanics and failure\, and transmural fluid and solid transport\, as possible contributions to aneurysmal disease. \n\n\n\nPrint PDF
URL:https://engineering.wisc.edu/event/bme-seminar-series-jessica-wagenseil-phd/
LOCATION:1003 (Tong Auditorium) Engineering Centers Building\, 1550 Engineering Drive\, Madison\, WI\, 53706\, United States
CATEGORIES:Biomedical Engineering,Seminar
ATTACH;FMTTYPE=image/jpeg:https://engineering.wisc.edu/wp-content/uploads/2024/11/Seminar-Graphic-Fall2024-1.avif
ORGANIZER;CN="Department of Biomedical Engineering":MAILTO:bmehelp@bme.wisc.edu
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