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DTSTART;TZID=America/Chicago:20250909T160000
DTEND;TZID=America/Chicago:20250909T170000
DTSTAMP:20260405T142032
CREATED:20250827T162451Z
LAST-MODIFIED:20250828T132443Z
UID:10001284-1757433600-1757437200@engineering.wisc.edu
SUMMARY:CBE Seminar Series: Harry Atwater
DESCRIPTION:Harry AtwaterDepartment of Applied Physics and Materials ScienceCalifornia Institute of TechnologyPasadena\, California \n\n\n\n\n\n\n\nDesign of Materials and Devices for Carbon Dioxide Capture and Conversion using Sunlight\n\n\n\nOver the next two decades\, science advances will be needed to enable scalable technologies for i) direct capture of dilute CO2 at the gigaton scale as well as ii) CO2 reduction to fuels\, chemicals\, and materials\, powered by renewable energy or directly by sunlight. I will discuss materials and device advances needed for a promising capture approach\, a scalable energy-efficient route to direct ocean capture of CO2\, via an electrochemical pH swing. This scheme utilizes bipolar membrane electrodialysis to create the pH swing required to capture CO2 drawn down into the ocean in the form of dissolved inorganic carbon. I will also explore approaches for directly generating liquid solar fuels from carbon dioxide\, sunlight\, water. This requires new photocatalysts and thermocatalytic structures to facilitate transfer of electrons\, protons\, and reactants\, to selectively yield multi-carbon products at semiconductor photoelectrode surfaces and catalytic sites. Two tandem reaction schemes for liquid solar fuel generation from CO2 will be discussed: i) a three-terminal tandem photoelectrode with two monolithically integrated but distinct catalytic centers operating at independent potentials to yield products via a cascaded reaction sequence\, and ii) a tandem photoelectrochemical/solar thermocatalytic cascade that uses electrochemically synthesized ethylene\, carbon monoxide and hydrogen as intermediates to yield multi-carbon products (butene\, hexene\, and heavier hydrocarbons) synthesized via solar-driven thermocatalytic reactions.
URL:https://engineering.wisc.edu/event/cbe-seminar-series-harry-atwater/
LOCATION:Wisconsin
CATEGORIES:Chemical & Biological Engineering,Seminar
ATTACH;FMTTYPE=image/jpeg:https://engineering.wisc.edu/wp-content/uploads/2023/02/2023_CBE-sem-series-web-header-scaled.webp
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Chicago:20250911T160000
DTEND;TZID=America/Chicago:20250911T170000
DTSTAMP:20260405T142032
CREATED:20250811T142145Z
LAST-MODIFIED:20250811T142147Z
UID:10001259-1757606400-1757610000@engineering.wisc.edu
SUMMARY:ME 150th Celebration: Distinguished Alumni\, Dean Devesh Ranjan
DESCRIPTION:To celebrate 150 years of Mechanical Engineering at the University of Wisconsin – Madison\, the Department of Mechanical Engineering will feature distinguished alumni in mechanical engineering and engineering mechanics who have made a lasting impact on the field. Newly appointed dean to the College of Engineering\, Devesh Ranjan graduated from UW-Madison with his master’s degree in 2005 and his doctorate in 2007. To learn more about Dean Ranjan’s experience\, please join us for this installment of our ME 903: Graduate Student Lecture series.
URL:https://engineering.wisc.edu/event/me-150th-celebration-distinguished-alumni-dean-devesh-ranjan/
LOCATION:3M Auditorium\, rm 1106 Mechanical Engineering Building\, 1513 University Ave\, Madison\, 53711
CATEGORIES:Alumni events,Featured Guest Speaker,Mechanical Engineering,Seminar
ATTACH;FMTTYPE=image/png:https://engineering.wisc.edu/wp-content/uploads/2025/08/Event-Graphics-for-Calendar.avif
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Chicago:20250911T160000
DTEND;TZID=America/Chicago:20250911T170000
DTSTAMP:20260405T142032
CREATED:20250827T162412Z
LAST-MODIFIED:20250827T162414Z
UID:10001285-1757606400-1757610000@engineering.wisc.edu
SUMMARY:CBE Seminar Series: Ted Lightfoot
DESCRIPTION:Reception 3:30-4:00pm (2-story space besides 1610 E Hall) \n\n\n\nE.J. (Ted) LightfootTed Lightfoot ConsultingAmherst\, NY \n\n\n\n\n\n\n\nTransport Phenomena and Coating Science\n\n\n\nIn the 1960s Transport Phenomena triggered a shift in engineering education from engineering technology to engineering science. In the 1970s the more advanced coating companies (in the photographic\, magnetic tape\, and paper industries) began to undertake fundamental studies of the formation and drying of thin liquid layers on a moving solid substrate. Over the next fifty years\, tremendous progress has been made in understanding how transport phenomena (including rheology\, fluid mechanics\, and both internal and external mass transport) affect the production of coated layers applied to a range of substrates. This talk will review the history of mathematical modeling of the transport processes encountered in the coating industry as well as several opportunities for fundamental advancement that could benefit battery and fuel cell manufacture as well as the development of Perovskite solar cells. Although the talk will review the use of mathematical tools to describe key physical phenomena important to the industry\, the emphasis will be on human factors — both cultural biases and the individual people who have shaped the field.
URL:https://engineering.wisc.edu/event/cbe-seminar-series-ted-lightfoot/
LOCATION:Wisconsin
CATEGORIES:Chemical & Biological Engineering,Seminar
ATTACH;FMTTYPE=image/jpeg:https://engineering.wisc.edu/wp-content/uploads/2023/02/2023_CBE-sem-series-web-header-scaled.webp
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Chicago:20250912T120500
DTEND;TZID=America/Chicago:20250912T125500
DTSTAMP:20260405T142032
CREATED:20250825T192505Z
LAST-MODIFIED:20250908T171933Z
UID:10001272-1757678700-1757681700@engineering.wisc.edu
SUMMARY:Mechanics Seminar: Professor Joseph Andrews
DESCRIPTION:The Mechanics Seminar Series is a weekly seminar given by campus and visiting speakers on topics across the spectrum of mechanics research (solids\, fluids\, and dynamics). Professor Joseph Andrews is a professor at UW-Madison.
URL:https://engineering.wisc.edu/event/mechanics-seminar-professor-xuanhe-zhao/
LOCATION:3M Auditorium\, rm 1106 Mechanical Engineering Building\, 1513 University Ave\, Madison\, 53711
CATEGORIES:Mechanical Engineering,Seminar
ATTACH;FMTTYPE=image/jpeg:https://engineering.wisc.edu/wp-content/uploads/2024/08/Event-Graphics-for-Calendar-11-jpg.avif
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Chicago:20250915T120000
DTEND;TZID=America/Chicago:20250915T130000
DTSTAMP:20260405T142032
CREATED:20250827T165905Z
LAST-MODIFIED:20250905T181419Z
UID:10001290-1757937600-1757941200@engineering.wisc.edu
SUMMARY:BME Seminar Series: Allen Garner PhD
DESCRIPTION:Electrical Manipulation of Biological Cells: Models and Applications\n\n\n\n\n\n\n\nAllen Garner\, PhD\, PEProfessor\, Graduate Program ChairSchool of Nuclear EngineeringPurdue University \n\n\n\nElectric waveforms\, including electric pulses (EPs) and alternating current (AC) fields\, such as radiofrequency and high-power microwaves\, can induce deleterious or beneficial effects that require additional characterization. We combine thermal models with the Smoluchowski equation to assess the interactions of EP and AC waveforms with biological cells. We further develop a computationally efficient model based on the asymptotic Smoluchowski to screen biological response over seven orders of magnitude of pulse duration with excellent agreement between simulated electroporation and experimental observations. Applications in microorganism inactivation\, natural products for cancer therapy\, platelet activation\, and stem cell stimulation will be discussed. \n\n\n\nPrint PDF
URL:https://engineering.wisc.edu/event/bme-seminar-series-allen-garner-phd/
LOCATION:1003 (Tong Auditorium) Engineering Centers Building\, 1550 Engineering Drive\, Madison\, WI\, 53706\, United States
CATEGORIES:Biomedical Engineering,Seminar
ATTACH;FMTTYPE=image/jpeg:https://engineering.wisc.edu/wp-content/uploads/2024/11/Seminar-Graphic-Fall2024-1.avif
ORGANIZER;CN="Department of Biomedical Engineering":MAILTO:bmehelp@bme.wisc.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Chicago:20250918T160000
DTEND;TZID=America/Chicago:20250918T170000
DTSTAMP:20260405T142032
CREATED:20250811T163746Z
LAST-MODIFIED:20250915T161826Z
UID:10001263-1758211200-1758214800@engineering.wisc.edu
SUMMARY:ME 903 Graduate Seminar: Mike Molnar
DESCRIPTION:The ME 903: Graduate Student Lecture Series features campus and visiting speakers who present on a variety of research topics in the field of mechanical engineering. Michael Molnar (BSME ’85) is the founding director of the Advanced Manufacturing National Program Office at NIST.  \n\n\n\nPresentation Title: The Federal Role in Accelerating Technology and Manufacturing Innovation \n\n\n\nAbstract: The development of critical and emerging technologies plays a key role in U.S. national and economic security. Since the founding of our nation the role of the federal government has been clear on national security but a matter of considerable debate on the broader economic security. Beginning with Alexander Hamilton’s Report on Manufactures through Vannevar Bush’s Science\, the Endless Frontier\, to today – the principles of an innovation policy are clear. What though is the federal role in industrial policy with a free market system? \n\n\n\nSeveral successful models have emerged\, all having elements of partnership to support industry and academia. Manufacturing USA is an example of industry-led public private partnerships. Established as a program just ten years ago as applied research institutes on emerging technologies\, these institutes feature mass collaboration of industry and academia on projects of technology acceleration\, supply chain and workforce development. Some 18 institutes are currently in the national network with a new institute on Artificial Intelligence for Resilient Manufacturing planned this year. The talk concludes with briefly contrasting other engagement models\, such as Operation Warp Speed\, for accelerating technology. \n\n\n\nBio: Mike is the founding director of the Advanced Manufacturing National Program Office\, the interagency team responsible for the Manufacturing USA network of applied research manufacturing innovation institutes. He also leads the NIST Office of Advanced Manufacturing and serves as co-chair of the National Science and Technology Council\, Subcommittee on Advanced Manufacturing – the White House team responsible for the National Strategic Plan for Advanced Manufacturing. Prior to joining federal service in 2011 Mike had a successful industry career\, including 25 years leading manufacturing and technology development at Cummins\, a U.S. based global company that designs and manufactures engines and power generation products. Mike is a proud Badger\, with two of his degrees from the University of Wisconsin – a Mechanical Engineering B.S. and one of the first graduates of the Manufacturing Systems Engineering Masters program.
URL:https://engineering.wisc.edu/event/me-903-graduate-seminar-mike-molnar/
LOCATION:3M Auditorium\, rm 1106 Mechanical Engineering Building\, 1513 University Ave\, Madison\, 53711
CATEGORIES:Mechanical Engineering,Seminar
ATTACH;FMTTYPE=image/jpeg:https://engineering.wisc.edu/wp-content/uploads/2024/08/Event-Graphics-for-Calendar-12-jpg.avif
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Chicago:20250918T160000
DTEND;TZID=America/Chicago:20250918T170000
DTSTAMP:20260405T142032
CREATED:20250827T163139Z
LAST-MODIFIED:20250827T163141Z
UID:10001286-1758211200-1758214800@engineering.wisc.edu
SUMMARY:CBE Seminar Series: Pramod Wangikar
DESCRIPTION:Seminar 9-10am at Union South Landmark Room \n\n\n\nPramod WangikarChair Professor for Green Chemistry and Industrial BiotechnologyDepartment of Chemical EngineeringIndian Institute of Technology BombayMumbai\, India \n\n\n\n\n\n\n\nHarnessing Metabolomics for Precision Medicine and Fermentation\n\n\n\nMetabolomics is an emerging tool in bioengineering research\, based on profiling hundreds of metabolites in biological systems to provide a detailed view of cellular metabolism. In this evolving field\, success hinges on advanced data acquisition methods\, particularly mass spectrometry coupled with liquid chromatography (LC–MS) or gas chromatography (GC–MS). We present specific use cases from our research that demonstrate the transformative potential of metabolomics in understanding and manipulating biological systems for healthcare and industrial applications: \n\n\n\n\nBiomarker Discovery in Metabolic Disorders: We used untargeted metabolomics to discover novel biomarkers for chronic metabolic disorders. In patients with type 2 diabetes (T2D)\, we identified distinct panels of metabolites associated with the risk of kidney and cardiovascular complications. These biomarkers hold potential for diagnostic tools offering greater predictive power and clinical efficacy than the standard glucose test.\n\n\n\nFermentation Optimization via Spent Media Analysis: Metabolomic analysis of spent culture media reveals critical insights into cellular metabolism in fermentation processes. By integrating these data with genome-scale metabolic models through constraint-based modeling\, we optimized nutrient supplementation strategies\, achieving substantial improvements in product yield with minimal experimental trials. \n\n\n\n\nHandling large\, complex datasets from untargeted metabolomics presents a significant challenge due to data complexity and noise. To streamline the analysis of such large metabolomics datasets\, we developed MSOne\, an AI-based platform that automates and accelerates data processing. Additionally\, we leverage MetaMine\, a repository derived from thousands of public-domain metabolomics studies that supports comparative analysis and meta-level insights. Together\, these tools serve as essential resources for addressing challenges in large-scale metabolomics data handling and interpretation\, reinforcing the promise of metabolomics in precision medicine and industrial biotechnology
URL:https://engineering.wisc.edu/event/cbe-seminar-series-pramod-wangikar/
LOCATION:Wisconsin
CATEGORIES:Chemical & Biological Engineering,Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Chicago:20250919T120500
DTEND;TZID=America/Chicago:20250919T125500
DTSTAMP:20260405T142032
CREATED:20250825T193504Z
LAST-MODIFIED:20250915T161922Z
UID:10001273-1758283500-1758286500@engineering.wisc.edu
SUMMARY:Mechanics Seminar: Professor Matthew Brake
DESCRIPTION:The Mechanics Seminar Series is a weekly seminar given by campus and visiting speakers on topics across the spectrum of mechanics research (solids\, fluids\, and dynamics). Professor Matthew Brake is an Associate Professor at Rice University.  \n\n\n\nPresentation Title: Videographic Modal Analysis \n\n\n\nAbstract: Experimental modal analysis is a classical tool that has formed the basis of modern vibration testing and qualification. Despite this\, the process of experimental modal analysis is largely reliant upon techniques from over 60 years ago. Typical experiments of large structures can take months of planning and setup\, and require thousands of channels of accelerometer data. To lower the cost and time associated with vibration testing\, Videographic Modal Analysis (VMA) combines recent advances in data science\, image processing\, and traditional modal analysis concepts. First\, natural frequencies are identified from videos of an experiment using a deep learning algorithm. Once these frequencies are identified\, optical flow\, phase-based motion magnification\, and edge detection techniques are automatically applied to quantitatively characterize the mode shapes of the structure. Without instrumentation\, we can now identify mode shapes and natural frequencies of arbitrary structures in real-world settings (not just beams vibrating in labs!). This talk will present the science behind VMA and demonstrate its applicability. \n\n\n\nBio: Prof. Brake started at Rice University in 2016 after working at Sandia National Laboratories for nine years. Prior to Sandia\, Prof. Brake graduated from Carnegie Mellon University in 2007. Prof. Brake has been elected to several leadership positions\, including as the director of the International Committee on Joint Mechanics\, the chair of the Nonlinear Dynamics Technical Division of SEM\, and the chair of the ASME Technical Committee on Vibration and Sound. He is a recipient of the 2012 Presidential Early Career Award for Scientists and Engineers\, the 2018 C.D. Mote Jr Early Career Award\, and the National Science Foundation Career Award. His primary research interests are in data-driven experimentation\, multi-scale and multi-physics modeling\, vibration\, tribology\, uncertainty propagation\, structural health monitoring\, and nonlinear dynamics.
URL:https://engineering.wisc.edu/event/mechanics-seminar-professor-matthew-brake/
LOCATION:3M Auditorium\, rm 1106 Mechanical Engineering Building\, 1513 University Ave\, Madison\, 53711
CATEGORIES:Mechanical Engineering,Seminar
ATTACH;FMTTYPE=image/jpeg:https://engineering.wisc.edu/wp-content/uploads/2024/08/Event-Graphics-for-Calendar-11-jpg.avif
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Chicago:20250922T120000
DTEND;TZID=America/Chicago:20250922T130000
DTSTAMP:20260405T142032
CREATED:20250827T170410Z
LAST-MODIFIED:20250910T203228Z
UID:10001292-1758542400-1758546000@engineering.wisc.edu
SUMMARY:BME Seminar Series: Marty Pagel\, PhD
DESCRIPTION:Molecular Imaging of the Tumor Microenvironment\n\n\n\n\n\n\n\nMarty Pagel\, PhDProfessorDepartment of Medical PhysicsDepartment of RadiologyUniversity of Wisconsin-Madison \n\n\n\nAbstract:Tumor acidosis\, hypoxia\, and vascular perfusion are well-known characteristics of the tumor microenvironment. We have developed MRI\, MR Fingerprinting\, PET/MRI\, electron paramagnetic resonance imaging (EPRI)\, and photoacoustic imaging (PAI) to quantitatively measure extracellular pH\, oxygenation\, and pharmacokinetic transport rates in solid tumors. We apply these molecular imaging methods to preclinical tumor models\, and we have translated some of our methods to evaluate patients who have cancer. We are especially focused on employing molecular imaging to predict treatment effect before starting therapy\, and to evaluate the early response to treatment\, during evaluations of chemotherapy\, radiotherapy and immunotherapy. This presentation will discuss a variety of molecular imaging methods and research applications\, and also discuss a value proposition for molecular imaging. \n\n\n\nPrint PDF
URL:https://engineering.wisc.edu/event/bme-seminar-series-marty-pagel-phd/
LOCATION:1003 (Tong Auditorium) Engineering Centers Building\, 1550 Engineering Drive\, Madison\, WI\, 53706\, United States
CATEGORIES:Biomedical Engineering,Seminar
ATTACH;FMTTYPE=image/jpeg:https://engineering.wisc.edu/wp-content/uploads/2024/11/Seminar-Graphic-Fall2024-1.avif
ORGANIZER;CN="Department of Biomedical Engineering":MAILTO:bmehelp@bme.wisc.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Chicago:20250923T160000
DTEND;TZID=America/Chicago:20250923T170000
DTSTAMP:20260405T142032
CREATED:20250827T163455Z
LAST-MODIFIED:20250827T163458Z
UID:10001287-1758643200-1758646800@engineering.wisc.edu
SUMMARY:CBE Seminar Series: David Schaffer
DESCRIPTION:David SchafferDepartment of Chemical and Biomolecular EngineeringUniversity of California-Berkeley Berkeley\, CA \n\n\n\n\n\n\n\nDirected Evolution of New AAV Vectors for Clinical Gene Therapy\n\n\n\nGene therapy has experienced an increasing number of successful human clinical trials\, leading to 6 FDA approved products using delivery vectors based on adeno-associated viruses (AAV). These successes were possible due to the identification of specific disease targets for which natural variants of AAV were sufficient. However\, vectors face a number of barriers and shortcomings that preclude their extension to most human diseases\, including limited delivery efficiency to target cells\, pre-existing antibodies against AAVs\, suboptimal biodistribution\, limited spread within tissues\, and/or an inability to target delivery to specific cells. These barriers are not surprising\, since the parent viruses upon which vectors are based were not evolved by nature for our convenience to use as human therapeutics. Unfortunately\, for most applications\, there is insufficient mechanistic knowledge of underlying virus structure-function relationships to empower rational design improvements. As an alternative\, for over two decades we have been implementing directed evolution–the iterative genetic diversification of the viral genome and functional selection for desired properties–to engineer highly optimized\, next generation AAV variants for efficient and targeted delivery to any cell or tissue target. We have genetically diversified AAV using a broad range of approaches from fully random (e.g. error prone PCR) to computationally guided (e.g. by machine learning). The resulting large (~109) libraries are then functionally selected for substantially enhanced delivery\, yielding AAVs capable of highly efficient therapeutic gene delivery. Our variants have been effective in both animal models and in 6 human clinical trials to date\, and results from both will be discussed.
URL:https://engineering.wisc.edu/event/cbe-seminar-series-david-schaffer/
LOCATION:Wisconsin
CATEGORIES:Chemical & Biological Engineering,Seminar
ATTACH;FMTTYPE=image/jpeg:https://engineering.wisc.edu/wp-content/uploads/2023/02/2023_CBE-sem-series-web-header-scaled.webp
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Chicago:20250926T120500
DTEND;TZID=America/Chicago:20250926T125500
DTSTAMP:20260405T142032
CREATED:20250825T193745Z
LAST-MODIFIED:20250915T162031Z
UID:10001274-1758888300-1758891300@engineering.wisc.edu
SUMMARY:Midwest Mechanics Seminar: Professor Daniel Chung
DESCRIPTION:The Mechanics Seminar Series is a weekly seminar given by campus and visiting speakers on topics across the spectrum of mechanics research (solids\, fluids\, and dynamics). Professor Daniel Chung is an Associate Professor at The University of Melbourne.  \n\n\n\nPresentation Title: Fluid mechanics of riblets drag reduction \n\n\n\nAbstract: Riblets are a surface texture composed of tiny ribs applied on aircraft skin to reduce drag\, which saves on fuel\, increases the payload and extends the range. To the fast-moving turbulent air that flows over it\, riblets turn out to be smoother\, generating less skin friction\, than a perfectly flat surface. However\, riblet performance is highly sensitive to their cross-sectional shape and features\, which is bad news because the micron-sized ribs\, imperceptible to the naked eye and challenging to measure even with precision instruments\, are impossible to manufacture and maintain perfectly. Thus\, accurate tolerancing\, not only for manufacture but also for lifetime wear planning and monitoring\, is key to this technology\, requiring predictive capability of the kind that derives from advances in basic understanding. In this regard\, I will present some of the progress we have made in the last few years\, building on decades of research\, on the fluid mechanics of turbulence over riblet surfaces. \n\n\n\nThe support of the Australian Research Council\, Cooperative Research Australia and the U.S. Air Force Office of Scientific Research FA2386-23-1-4071 is gratefully acknowledged. \n\n\n\nBio: Daniel is an associate professor in the Department of Mechanical Engineering at the University of Melbourne. He obtained his bachelor’s degree in engineering and computer science from the University of Melbourne in 2003\, and his PhD in aeronautics from Caltech in 2009. He was a postdoc at the Jet Propulsion Laboratory before joining the University of Melbourne in 2012. Daniel’s research uses computational fluid dynamics\, where he tries to distil turbulent flows into simplified problems and to build physics-based models for prediction. Recently\, he has been interested in understanding and controlling turbulent flow and thermal convection over rough surfaces\, riblets and moving wavy surfaces.
URL:https://engineering.wisc.edu/event/midwest-mechanics-seminar-professor-daniel-chung/
LOCATION:3M Auditorium\, rm 1106 Mechanical Engineering Building\, 1513 University Ave\, Madison\, 53711
CATEGORIES:Mechanical Engineering,Seminar
ATTACH;FMTTYPE=image/jpeg:https://engineering.wisc.edu/wp-content/uploads/2024/08/Event-Graphics-for-Calendar-11-jpg.avif
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Chicago:20250929T120000
DTEND;TZID=America/Chicago:20250929T130000
DTSTAMP:20260405T142032
CREATED:20250827T170251Z
LAST-MODIFIED:20250910T203342Z
UID:10001291-1759147200-1759150800@engineering.wisc.edu
SUMMARY:BME Seminar Series: Hua Wang\, PhD
DESCRIPTION:Molecular to Systemic Engineering of Immune Cells for Robust Immunotherapy\n\n\n\n\n\n\n\nHua Wang\, PhDAssociate ProfessorDepartment of Materials Science and EngineeringUniversity of Illinois at Urbana-Champaign \n\n\n\nAbstract:Immunotherapy has achieved significant clinical progress for the treatment of cancer and other diseases over the past decade\, but challenges\, including low patient responses\, off-target side effects\, and poor efficacy against solid tumors and autoimmune disorders\, remain. One of our research interests is to understand how immune cells (e.g.\, dendritic cells (DCs)) can be manipulated or engineered using chemistry\, material\, and chemical biology approaches\, in order to develop effective therapies for cancer and other diseases. In this talk\, I will present our recent efforts in molecular\, systemic\, and in situ engineering of DCs and further development of robust cancer vaccines. These include molecules and polymers that can interact with DC membrane and thus activate DCs\, and macroporous materials that can actively recruit and program DCs in situ. I will then conclude my talk with several short stories along the line of metabolic glycan labeling\, another key technology in my lab\, regarding how we made it possible to precisely modulate cells that are historically challenging to engineer. \n\n\n\nPrint PDF
URL:https://engineering.wisc.edu/event/bme-seminar-series-hua-wang-phd/
LOCATION:1003 (Tong Auditorium) Engineering Centers Building\, 1550 Engineering Drive\, Madison\, WI\, 53706\, United States
CATEGORIES:Biomedical Engineering,Seminar
ATTACH;FMTTYPE=image/jpeg:https://engineering.wisc.edu/wp-content/uploads/2024/11/Seminar-Graphic-Fall2024-1.avif
ORGANIZER;CN="Department of Biomedical Engineering":MAILTO:bmehelp@bme.wisc.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Chicago:20250930T160000
DTEND;TZID=America/Chicago:20250930T170000
DTSTAMP:20260405T142032
CREATED:20250827T163602Z
LAST-MODIFIED:20250909T150710Z
UID:10001288-1759248000-1759251600@engineering.wisc.edu
SUMMARY:CBE Seminar Series: Hal Alper
DESCRIPTION:Hal S. AlperProfessor & Cockrell Family Regents Chair in EngineeringDepartment of Chemical EngineeringUniversity of Texas-AustinAustin\, TX \n\n\n\n\n\n\n\nBeyond the test-tube: metabolic engineering for next-generation applications\n\n\n\nAdvances in metabolic engineering and synthetic biology can enable microbes to produce nearly any organic molecule of interest—from biofuels to biopolymers to pharmaceuticals. While this approach has fueled the industrial biotechnology\, new challenges arise for microbe engineering when considering non-conventional settings. This talk will highlight several unique application areas for metabolic engineering. First\, the use of engineered biology for the degradation of waste products (including plastics and other hydrophobic substrates) will be discussed considering the unique challenges required to consume these non-carbohydrate substrates. Second\, the use of a printable hydrogel system for encapsulating cells will be discussed as a means for both portable cultivation of engineered microbial systems as well as for responsive theranostics. Third\, the engineering of microbial factories for space environments will be discussed. Robust “space-ready” organisms require an understanding of how cells respond to the unique challenges and stressors of space including microgravity\, radiation\, and desiccation. Together\, these efforts demonstrate how to deploy metabolically engineered cells outside of traditional sugar-based bioreactor settings.
URL:https://engineering.wisc.edu/event/cbe-seminar-series-hal-alper/
LOCATION:Wisconsin
CATEGORIES:Chemical & Biological Engineering,Seminar
ATTACH;FMTTYPE=image/jpeg:https://engineering.wisc.edu/wp-content/uploads/2023/02/2023_CBE-sem-series-web-header-scaled.webp
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