BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//College of Engineering - University of Wisconsin-Madison - ECPv6.15.18//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-WR-CALNAME:College of Engineering - University of Wisconsin-Madison
X-ORIGINAL-URL:https://engineering.wisc.edu
X-WR-CALDESC:Events for College of Engineering - University of Wisconsin-Madison
REFRESH-INTERVAL;VALUE=DURATION:PT1H
X-Robots-Tag:noindex
X-PUBLISHED-TTL:PT1H
BEGIN:VTIMEZONE
TZID:America/Chicago
BEGIN:DAYLIGHT
TZOFFSETFROM:-0600
TZOFFSETTO:-0500
TZNAME:CDT
DTSTART:20240310T080000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0500
TZOFFSETTO:-0600
TZNAME:CST
DTSTART:20241103T070000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:-0600
TZOFFSETTO:-0500
TZNAME:CDT
DTSTART:20250309T080000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0500
TZOFFSETTO:-0600
TZNAME:CST
DTSTART:20251102T070000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:-0600
TZOFFSETTO:-0500
TZNAME:CDT
DTSTART:20260308T080000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0500
TZOFFSETTO:-0600
TZNAME:CST
DTSTART:20261101T070000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=America/Chicago:20250918T160000
DTEND;TZID=America/Chicago:20250918T170000
DTSTAMP:20260405T160515
CREATED:20250811T163746Z
LAST-MODIFIED:20250915T161826Z
UID:10001263-1758211200-1758214800@engineering.wisc.edu
SUMMARY:ME 903 Graduate Seminar: Mike Molnar
DESCRIPTION:The ME 903: Graduate Student Lecture Series features campus and visiting speakers who present on a variety of research topics in the field of mechanical engineering. Michael Molnar (BSME ’85) is the founding director of the Advanced Manufacturing National Program Office at NIST.  \n\n\n\nPresentation Title: The Federal Role in Accelerating Technology and Manufacturing Innovation \n\n\n\nAbstract: The development of critical and emerging technologies plays a key role in U.S. national and economic security. Since the founding of our nation the role of the federal government has been clear on national security but a matter of considerable debate on the broader economic security. Beginning with Alexander Hamilton’s Report on Manufactures through Vannevar Bush’s Science\, the Endless Frontier\, to today – the principles of an innovation policy are clear. What though is the federal role in industrial policy with a free market system? \n\n\n\nSeveral successful models have emerged\, all having elements of partnership to support industry and academia. Manufacturing USA is an example of industry-led public private partnerships. Established as a program just ten years ago as applied research institutes on emerging technologies\, these institutes feature mass collaboration of industry and academia on projects of technology acceleration\, supply chain and workforce development. Some 18 institutes are currently in the national network with a new institute on Artificial Intelligence for Resilient Manufacturing planned this year. The talk concludes with briefly contrasting other engagement models\, such as Operation Warp Speed\, for accelerating technology. \n\n\n\nBio: Mike is the founding director of the Advanced Manufacturing National Program Office\, the interagency team responsible for the Manufacturing USA network of applied research manufacturing innovation institutes. He also leads the NIST Office of Advanced Manufacturing and serves as co-chair of the National Science and Technology Council\, Subcommittee on Advanced Manufacturing – the White House team responsible for the National Strategic Plan for Advanced Manufacturing. Prior to joining federal service in 2011 Mike had a successful industry career\, including 25 years leading manufacturing and technology development at Cummins\, a U.S. based global company that designs and manufactures engines and power generation products. Mike is a proud Badger\, with two of his degrees from the University of Wisconsin – a Mechanical Engineering B.S. and one of the first graduates of the Manufacturing Systems Engineering Masters program.
URL:https://engineering.wisc.edu/event/me-903-graduate-seminar-mike-molnar/
LOCATION:3M Auditorium\, rm 1106 Mechanical Engineering Building\, 1513 University Ave\, Madison\, 53711
CATEGORIES:Mechanical Engineering,Seminar
ATTACH;FMTTYPE=image/jpeg:https://engineering.wisc.edu/wp-content/uploads/2024/08/Event-Graphics-for-Calendar-12-jpg.avif
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Chicago:20250915T120000
DTEND;TZID=America/Chicago:20250915T130000
DTSTAMP:20260405T160515
CREATED:20250827T165905Z
LAST-MODIFIED:20250905T181419Z
UID:10001290-1757937600-1757941200@engineering.wisc.edu
SUMMARY:BME Seminar Series: Allen Garner PhD
DESCRIPTION:Electrical Manipulation of Biological Cells: Models and Applications\n\n\n\n\n\n\n\nAllen Garner\, PhD\, PEProfessor\, Graduate Program ChairSchool of Nuclear EngineeringPurdue University \n\n\n\nElectric waveforms\, including electric pulses (EPs) and alternating current (AC) fields\, such as radiofrequency and high-power microwaves\, can induce deleterious or beneficial effects that require additional characterization. We combine thermal models with the Smoluchowski equation to assess the interactions of EP and AC waveforms with biological cells. We further develop a computationally efficient model based on the asymptotic Smoluchowski to screen biological response over seven orders of magnitude of pulse duration with excellent agreement between simulated electroporation and experimental observations. Applications in microorganism inactivation\, natural products for cancer therapy\, platelet activation\, and stem cell stimulation will be discussed. \n\n\n\nPrint PDF
URL:https://engineering.wisc.edu/event/bme-seminar-series-allen-garner-phd/
LOCATION:1003 (Tong Auditorium) Engineering Centers Building\, 1550 Engineering Drive\, Madison\, WI\, 53706\, United States
CATEGORIES:Biomedical Engineering,Seminar
ATTACH;FMTTYPE=image/jpeg:https://engineering.wisc.edu/wp-content/uploads/2024/11/Seminar-Graphic-Fall2024-1.avif
ORGANIZER;CN="Department of Biomedical Engineering":MAILTO:bmehelp@bme.wisc.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Chicago:20250912T120500
DTEND;TZID=America/Chicago:20250912T125500
DTSTAMP:20260405T160515
CREATED:20250825T192505Z
LAST-MODIFIED:20250908T171933Z
UID:10001272-1757678700-1757681700@engineering.wisc.edu
SUMMARY:Mechanics Seminar: Professor Joseph Andrews
DESCRIPTION:The Mechanics Seminar Series is a weekly seminar given by campus and visiting speakers on topics across the spectrum of mechanics research (solids\, fluids\, and dynamics). Professor Joseph Andrews is a professor at UW-Madison.
URL:https://engineering.wisc.edu/event/mechanics-seminar-professor-xuanhe-zhao/
LOCATION:3M Auditorium\, rm 1106 Mechanical Engineering Building\, 1513 University Ave\, Madison\, 53711
CATEGORIES:Mechanical Engineering,Seminar
ATTACH;FMTTYPE=image/jpeg:https://engineering.wisc.edu/wp-content/uploads/2024/08/Event-Graphics-for-Calendar-11-jpg.avif
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Chicago:20250911T160000
DTEND;TZID=America/Chicago:20250911T170000
DTSTAMP:20260405T160515
CREATED:20250827T162412Z
LAST-MODIFIED:20250827T162414Z
UID:10001285-1757606400-1757610000@engineering.wisc.edu
SUMMARY:CBE Seminar Series: Ted Lightfoot
DESCRIPTION:Reception 3:30-4:00pm (2-story space besides 1610 E Hall) \n\n\n\nE.J. (Ted) LightfootTed Lightfoot ConsultingAmherst\, NY \n\n\n\n\n\n\n\nTransport Phenomena and Coating Science\n\n\n\nIn the 1960s Transport Phenomena triggered a shift in engineering education from engineering technology to engineering science. In the 1970s the more advanced coating companies (in the photographic\, magnetic tape\, and paper industries) began to undertake fundamental studies of the formation and drying of thin liquid layers on a moving solid substrate. Over the next fifty years\, tremendous progress has been made in understanding how transport phenomena (including rheology\, fluid mechanics\, and both internal and external mass transport) affect the production of coated layers applied to a range of substrates. This talk will review the history of mathematical modeling of the transport processes encountered in the coating industry as well as several opportunities for fundamental advancement that could benefit battery and fuel cell manufacture as well as the development of Perovskite solar cells. Although the talk will review the use of mathematical tools to describe key physical phenomena important to the industry\, the emphasis will be on human factors — both cultural biases and the individual people who have shaped the field.
URL:https://engineering.wisc.edu/event/cbe-seminar-series-ted-lightfoot/
CATEGORIES:Chemical & Biological Engineering,Seminar
ATTACH;FMTTYPE=image/jpeg:https://engineering.wisc.edu/wp-content/uploads/2023/02/2023_CBE-sem-series-web-header-scaled.webp
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Chicago:20250911T160000
DTEND;TZID=America/Chicago:20250911T170000
DTSTAMP:20260405T160515
CREATED:20250811T142145Z
LAST-MODIFIED:20250811T142147Z
UID:10001259-1757606400-1757610000@engineering.wisc.edu
SUMMARY:ME 150th Celebration: Distinguished Alumni\, Dean Devesh Ranjan
DESCRIPTION:To celebrate 150 years of Mechanical Engineering at the University of Wisconsin – Madison\, the Department of Mechanical Engineering will feature distinguished alumni in mechanical engineering and engineering mechanics who have made a lasting impact on the field. Newly appointed dean to the College of Engineering\, Devesh Ranjan graduated from UW-Madison with his master’s degree in 2005 and his doctorate in 2007. To learn more about Dean Ranjan’s experience\, please join us for this installment of our ME 903: Graduate Student Lecture series.
URL:https://engineering.wisc.edu/event/me-150th-celebration-distinguished-alumni-dean-devesh-ranjan/
LOCATION:3M Auditorium\, rm 1106 Mechanical Engineering Building\, 1513 University Ave\, Madison\, 53711
CATEGORIES:Alumni events,Featured Guest Speaker,Mechanical Engineering,Seminar
ATTACH;FMTTYPE=image/png:https://engineering.wisc.edu/wp-content/uploads/2025/08/Event-Graphics-for-Calendar.avif
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Chicago:20250909T160000
DTEND;TZID=America/Chicago:20250909T170000
DTSTAMP:20260405T160515
CREATED:20250827T162451Z
LAST-MODIFIED:20250828T132443Z
UID:10001284-1757433600-1757437200@engineering.wisc.edu
SUMMARY:CBE Seminar Series: Harry Atwater
DESCRIPTION:Harry AtwaterDepartment of Applied Physics and Materials ScienceCalifornia Institute of TechnologyPasadena\, California \n\n\n\n\n\n\n\nDesign of Materials and Devices for Carbon Dioxide Capture and Conversion using Sunlight\n\n\n\nOver the next two decades\, science advances will be needed to enable scalable technologies for i) direct capture of dilute CO2 at the gigaton scale as well as ii) CO2 reduction to fuels\, chemicals\, and materials\, powered by renewable energy or directly by sunlight. I will discuss materials and device advances needed for a promising capture approach\, a scalable energy-efficient route to direct ocean capture of CO2\, via an electrochemical pH swing. This scheme utilizes bipolar membrane electrodialysis to create the pH swing required to capture CO2 drawn down into the ocean in the form of dissolved inorganic carbon. I will also explore approaches for directly generating liquid solar fuels from carbon dioxide\, sunlight\, water. This requires new photocatalysts and thermocatalytic structures to facilitate transfer of electrons\, protons\, and reactants\, to selectively yield multi-carbon products at semiconductor photoelectrode surfaces and catalytic sites. Two tandem reaction schemes for liquid solar fuel generation from CO2 will be discussed: i) a three-terminal tandem photoelectrode with two monolithically integrated but distinct catalytic centers operating at independent potentials to yield products via a cascaded reaction sequence\, and ii) a tandem photoelectrochemical/solar thermocatalytic cascade that uses electrochemically synthesized ethylene\, carbon monoxide and hydrogen as intermediates to yield multi-carbon products (butene\, hexene\, and heavier hydrocarbons) synthesized via solar-driven thermocatalytic reactions.
URL:https://engineering.wisc.edu/event/cbe-seminar-series-harry-atwater/
CATEGORIES:Chemical & Biological Engineering,Seminar
ATTACH;FMTTYPE=image/jpeg:https://engineering.wisc.edu/wp-content/uploads/2023/02/2023_CBE-sem-series-web-header-scaled.webp
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Chicago:20250731T110000
DTEND;TZID=America/Chicago:20250731T120000
DTSTAMP:20260405T160515
CREATED:20250729T140451Z
LAST-MODIFIED:20250729T162706Z
UID:10001257-1753959600-1753963200@engineering.wisc.edu
SUMMARY:ECE Research Seminar Series: Professor Carsten Ronning
DESCRIPTION:2321 Engineering Hall \n\n\n\nIon beams for photonics and quantum technology\n\n\n\n\n\n\n\nAbstract: \n\n\n\nIon beam technologies are today routine methods in electronic device manufacturing\, e.g. the production of a modern processor needs 20-30 ion implantation steps. On the other hand\, the 21 st Century is considered by many to be the century of light following a century of developments in electronics. Therefore\, Ronning will present several experiments for the manipulation of the optical properties of (nano)materials using ion beams\, as well as corresponding strategies for the realization of photonic and quantum devices. \n\n\n\nBio: \n\n\n\nCarsten Ronning\n\n\n\nCarsten Ronning is full professor and director of the Institute of Solid State Physics at the Friedrich Schiller University Jena\, Germany. He studied physics at the Universities of Bremen and Konstanz\, and completed his PhD thesis entitled “Diamond-like materials prepared via mass selected ion beam deposition” in 1996. After holding a post-doc position at the North Carolina State University (USA)\, he performed intense research at the University of Göttingen on thin films\, semiconductor physics as well as on semiconductor nanowires. He moved to the Friedrich Schiller University Jena in 2008\, where his group is today studying the synthesis\, modification and characterization of nano-scale solids\, where the optical properties of semiconductor nanowires and metasurfaces are in focus.
URL:https://engineering.wisc.edu/event/ece-research-seminar-series-professor-carsten-ronning/
LOCATION:2321 Engineering Hall\, 1415 Engineering Drive\, Madison\, 53711
CATEGORIES:Electrical & Computer Engineering,Seminar
ATTACH;FMTTYPE=image/jpeg:https://engineering.wisc.edu/wp-content/uploads/2025/02/ECE-Research-Seminar-Series.avif
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Chicago:20250728T110000
DTEND;TZID=America/Chicago:20250728T120000
DTSTAMP:20260405T160515
CREATED:20250718T151118Z
LAST-MODIFIED:20250718T152207Z
UID:10001253-1753700400-1753704000@engineering.wisc.edu
SUMMARY:ECE Research Seminar Series: Dr. Oliver Burrow
DESCRIPTION:2321 Engineering Hall \n\n\n\nCompact Cold-Atom Platforms Enabled by Grating MOTs and Progress to Real-World Quantum Sensing\n\n\n\n\n\n\n\nAbstract: \n\n\n\nLaser cooling of atoms is the first step in a wide range of atomic and molecular experiments\, where low temperatures enable precision measurements. Traditionally\, laser-cooling apparatus were large\, often approaching room-scale\, but over the past decade there have been concerted global efforts\, including the UK’s Quantum Hubs initiative\, to reduce their size\, weight\, power\, and cost to enable the real-world deployment of quantum technologies. \n\n\n\nThe University of Strathclyde developed the grating magneto-optical trap (gMOT)\, which replaces the traditional six-beam MOT optical-geometry with a single input beam and a diffractive optic. This greatly reduces system complexity\, eases miniaturisation\, and provides a large solid angle of optical access. Typical Rb gMOTs trap >10⁷ atoms from vapour and achieve microkelvin temperatures. Recent advances at Strathclyde include gMOT atomic fountains\, optical lattices with the gMOT optic as the reflector\, and integration with sub-wavelength RF cavities\, paving the way for compact atomic clocks with stabilities approaching 10⁻¹³  τ -1/2. \n\n\n\nAnother challenge is achieving compact vacuum systems suitable for laser cooling. In collaboration with industrial partners\, we have created centilitre-scale ultra-high vacuum chambers with integrated gMOT optics\, demonstrating long operational lifetimes without active pumping. When combined with packaged electronics and beam-launch optics\, these become true cold-atom platform subsystems\, requiring only a power supply and a fibre-coupled laser input. \n\n\n\nThese platforms are now being translated into field-ready quantum sensors through UK academic–industrial partnerships. Applications include compact atomic clocks (gClock) and hybrid classical–quantum inertial navigation systems\, with initial sea trials planned for 2025. \n\n\n\n\n\n\n\nBio: \n\n\n\nOliver Burrow\n\n\n\nDr. Oliver Burrow is a Research Fellow in the University of Strathclyde’s Experimental Quantum Optics and Photonics Group. He completed his MPhys in Physics with Theoretical Physics at the University of Manchester in 2011 before moving to the University of Liverpool\, where his studies were developing a prototype atom interferometer to probe the dark contents of the vacuum under the supervision of Dr Jon Coleman\, earning his PhD in 2016. That research group has since become a founding member of the AION and MAGIS collaborations\, which are developing cutting-edge atom interferometers for gravitational-wave detection. \n\n\n\nSince joining Strathclyde in 2015\, Dr. Burrow’s research has focused on developing compact components for laser cooling\, with a strong emphasis on knowledge exchange and industrial collaboration. He has played a key role in advancing gMOT optics with Kelvin Nanotechnology and in developing centilitre-scale ultra-high vacuum gMOT systems with CPI-TMD. These technologies have become integral to next-generation quantum sensors in the UK\, and he is now leading efforts at Strathclyde with industry to deploy these cold-atom platforms as core subsystems in practical quantum sensors. \n\n\n\nDr. Burrow’s visit is hosted by ECE Associate Professor Jennifer Choy\, and ECE Antoine-Bascom Professor and Jack St. Clair Kilby Professor Mikhail Kats
URL:https://engineering.wisc.edu/event/ece-research-seminar-series-dr-oliver-burrow/
LOCATION:2321 Engineering Hall\, 1415 Engineering Drive\, Madison\, 53711
CATEGORIES:Electrical & Computer Engineering,Seminar
ATTACH;FMTTYPE=image/jpeg:https://engineering.wisc.edu/wp-content/uploads/2025/02/ECE-Research-Seminar-Series.avif
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Chicago:20250428T120000
DTEND;TZID=America/Chicago:20250428T130000
DTSTAMP:20260405T160515
CREATED:20250204T172651Z
LAST-MODIFIED:20250407T164436Z
UID:10001149-1745841600-1745845200@engineering.wisc.edu
SUMMARY:BME Seminar Series: Jessica Wagenseil\, PhD
DESCRIPTION:Biomechanics of Thoracic Aortic Aneurysms\n\n\n\n\n\n\n\nJessica Wagenseil\, DScProfessor\, Mechanical Engineering and Materials ScienceVice Dean for Faculty AdvancementMcKelvey School of EngineeringWashington University \n\n\n\nAbstract:Thoracic aortic aneurysms are a dilation of the aortic wall that can be asymptomatic for many years until they dissect or rupture. Dissection or rupture is associated with a high mortality rate. Surgical replacement is the current treatment standard and is performed when the aortic aneurysm reaches a specified size or growth rate. However\, many aortic aneurysms fail before reaching these thresholds and many pass the thresholds without failing. We are interested in predicting how the aneurysm will grow\, remodel\, and fail in response to mechanical stimuli using mouse models of human aneurysmal disease. Data will be presented from our work on biomechanical metrics associated with aneurysms\, correlations between mechanical changes and biochemical signaling\, growth and remodeling predictions of aneurysm progression\, fluid-solid structure interaction modeling of aneurysm biomechanics and failure\, and transmural fluid and solid transport\, as possible contributions to aneurysmal disease. \n\n\n\nPrint PDF
URL:https://engineering.wisc.edu/event/bme-seminar-series-jessica-wagenseil-phd/
LOCATION:1003 (Tong Auditorium) Engineering Centers Building\, 1550 Engineering Drive\, Madison\, WI\, 53706\, United States
CATEGORIES:Biomedical Engineering,Seminar
ATTACH;FMTTYPE=image/jpeg:https://engineering.wisc.edu/wp-content/uploads/2024/11/Seminar-Graphic-Fall2024-1.avif
ORGANIZER;CN="Department of Biomedical Engineering":MAILTO:bmehelp@bme.wisc.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Chicago:20250421T120000
DTEND;TZID=America/Chicago:20250421T130000
DTSTAMP:20260405T160515
CREATED:20250204T172623Z
LAST-MODIFIED:20250407T164208Z
UID:10001148-1745236800-1745240400@engineering.wisc.edu
SUMMARY:BME Seminar Series: Alan Jassanof\, PhD
DESCRIPTION:Analyzing Brain-Wide Function Using New Molecular Imaging Tools\n\n\n\n\n\n\n\nAlan Jasanoff\, PhDProfessor of Biological Engineering and Brain and Cognitive SciencesMassachusetts Institute of Technology \n\n\n\nAbstract:Behavior and cognition depend on the integrated action of neural structures and populations distributed throughout the brain. Deciphering mechanisms by which this takes this place is both a tremendous scientific problem and a major engineering challenge\, because of the need to establish suitable measurement technologies. We are creating a set of molecular imaging tools that enable multiregional neural processing to be studied at a brain-wide scale in rodents and nonhuman primates. Here we will describe how a novel genetically encoded activity reporter we have engineered enables information flow in virally labeled neural circuitry to be monitored by fMRI. Using the reporter to perform functional imaging of synaptically defined cell populations in the rat somatosensory system\, we show how activity is transformed within brain regions to yield characteristics specific to distinct output projections. We also show how this approach enables regional activity phenomena to be modeled in terms of inputs\, in a paradigm that we are extending to address circuit-level origins of functional specialization in marmoset brains. In the second part of the talk\, we will discuss how some of our MRI tools now enable the detection of optical reporters in deep neural tissue. We use novel imaging probes to detect luminescent proteins\, yielding a hybrid optical/MRI noninvasive imaging modality that surpasses limitations of conventional methods. This work demonstrates the possibility of investigating diverse brain-wide processing phenomena using advanced molecular neuroimaging methods. \n\n\n\nPrint PDF
URL:https://engineering.wisc.edu/event/bme-seminar-series-alan-jassanof-phd/
LOCATION:1003 (Tong Auditorium) Engineering Centers Building\, 1550 Engineering Drive\, Madison\, WI\, 53706\, United States
CATEGORIES:Biomedical Engineering,Seminar
ATTACH;FMTTYPE=image/jpeg:https://engineering.wisc.edu/wp-content/uploads/2024/11/Seminar-Graphic-Fall2024-1.avif
ORGANIZER;CN="Department of Biomedical Engineering":MAILTO:bmehelp@bme.wisc.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Chicago:20250407T120000
DTEND;TZID=America/Chicago:20250407T130000
DTSTAMP:20260405T160515
CREATED:20250204T172547Z
LAST-MODIFIED:20250401T162322Z
UID:10001147-1744027200-1744030800@engineering.wisc.edu
SUMMARY:BME Seminar Series: Daniel Gallego-Perez\, PhD
DESCRIPTION:Nanotransfection-driven gene and cell therapies\n\n\n\n\n\n\n\nDaniel Gallego-Perez\, PhDEdgar C. Hendrickson Chair in Biomedical EngineeringProfessor\, Surgery GeneralThe Ohio State University \n\n\n\nAbstract:Gene and engineered cell therapies hold transformative potential for treating a wide range of conditions. However\, current approaches face significant practical and translational challenges\, including a heavy reliance on viral vectors and high variability\, which often result in inefficient or unpredictable outcomes. To address these limitations\, we developed a novel nanotechnology-based approach that enables deterministic cell (in vitro) or tissue nano-transfection (TNT) (in vivo) without the need for viral vectors. These platform technologies offer a minimally disruptive and non-viral solution\, making them particularly suited for complex disease systems such as neurodegenerative conditions and metabolic disorders. Nano-transfection chips were manufactured from silicon or polymeric track etched membranes using cleanroom-based approaches\, as described previously. These chips were then used to nanotransfect skin cells\, in vitro or in vivo\, with pro-vasculogenic or pro-adipogenic gene cocktails\, which were then evaluated (for their therapeutic potential) in different murine models of neurodegenerative conditions\, including ischemic stroke\, and Alzheimer’s disease (AD)\, as well as models of metabolic dysfunction. Different molecular\, histological\, and functional outcomes studies were conducted to assess the extent to which these therapies mitigated disease burden in each model. In murine models of ischemic stroke\, nanotransfected fibroblasts improved brain vascularization\, perfusion\, as well as neuroprotection and neuroregeneration in the motor cortex\, which led to improved motor function. In murine models of AD\, nanotransfected fibroblasts led to improved brain vascularization\, perfusion\, and reduced amyloid beta load. This also correlated with improved memory and cognitive function. Finally\, in murine models of metabolic dysfunction\, TNT-treated skin cells were successfully coopted to partially fulfill brown adipogenic functions\, which led to improved weight control and cardiometabolic function. Overall\, these findings highlight the potential of cell and tissue nano-transfection to drive therapeutic processes for restoring damaged or diseased tissue structure and function\, paving the way for innovative treatments across diverse pathological conditions. \n\n\n\nPrint PDF
URL:https://engineering.wisc.edu/event/bme-seminar-series-daniel-gallego-perez-phd/
LOCATION:1003 (Tong Auditorium) Engineering Centers Building\, 1550 Engineering Drive\, Madison\, WI\, 53706\, United States
CATEGORIES:Biomedical Engineering,Seminar
ATTACH;FMTTYPE=image/jpeg:https://engineering.wisc.edu/wp-content/uploads/2024/11/Seminar-Graphic-Fall2024-1.avif
ORGANIZER;CN="Department of Biomedical Engineering":MAILTO:bmehelp@bme.wisc.edu
END:VEVENT
END:VCALENDAR