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SUMMARY:BME Seminar Series: Marty Pagel\, PhD
DESCRIPTION:Molecular Imaging of the Tumor Microenvironment\n\n\n\n\n\n\n\nMarty Pagel\, PhDProfessorDepartment of Medical PhysicsDepartment of RadiologyUniversity of Wisconsin-Madison \n\n\n\nAbstract:Tumor acidosis\, hypoxia\, and vascular perfusion are well-known characteristics of the tumor microenvironment. We have developed MRI\, MR Fingerprinting\, PET/MRI\, electron paramagnetic resonance imaging (EPRI)\, and photoacoustic imaging (PAI) to quantitatively measure extracellular pH\, oxygenation\, and pharmacokinetic transport rates in solid tumors. We apply these molecular imaging methods to preclinical tumor models\, and we have translated some of our methods to evaluate patients who have cancer. We are especially focused on employing molecular imaging to predict treatment effect before starting therapy\, and to evaluate the early response to treatment\, during evaluations of chemotherapy\, radiotherapy and immunotherapy. This presentation will discuss a variety of molecular imaging methods and research applications\, and also discuss a value proposition for molecular imaging. \n\n\n\nPrint PDF
URL:https://engineering.wisc.edu/event/bme-seminar-series-marty-pagel-phd/
LOCATION:1003 (Tong Auditorium) Engineering Centers Building\, 1550 Engineering Drive\, Madison\, WI\, 53706\, United States
CATEGORIES:Biomedical Engineering,Seminar
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ORGANIZER;CN="Department of Biomedical Engineering":MAILTO:bmehelp@bme.wisc.edu
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DTSTART;TZID=America/Chicago:20250923T160000
DTEND;TZID=America/Chicago:20250923T170000
DTSTAMP:20260405T160055
CREATED:20250827T163455Z
LAST-MODIFIED:20250827T163458Z
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SUMMARY:CBE Seminar Series: David Schaffer
DESCRIPTION:David SchafferDepartment of Chemical and Biomolecular EngineeringUniversity of California-Berkeley Berkeley\, CA \n\n\n\n\n\n\n\nDirected Evolution of New AAV Vectors for Clinical Gene Therapy\n\n\n\nGene therapy has experienced an increasing number of successful human clinical trials\, leading to 6 FDA approved products using delivery vectors based on adeno-associated viruses (AAV). These successes were possible due to the identification of specific disease targets for which natural variants of AAV were sufficient. However\, vectors face a number of barriers and shortcomings that preclude their extension to most human diseases\, including limited delivery efficiency to target cells\, pre-existing antibodies against AAVs\, suboptimal biodistribution\, limited spread within tissues\, and/or an inability to target delivery to specific cells. These barriers are not surprising\, since the parent viruses upon which vectors are based were not evolved by nature for our convenience to use as human therapeutics. Unfortunately\, for most applications\, there is insufficient mechanistic knowledge of underlying virus structure-function relationships to empower rational design improvements. As an alternative\, for over two decades we have been implementing directed evolution–the iterative genetic diversification of the viral genome and functional selection for desired properties–to engineer highly optimized\, next generation AAV variants for efficient and targeted delivery to any cell or tissue target. We have genetically diversified AAV using a broad range of approaches from fully random (e.g. error prone PCR) to computationally guided (e.g. by machine learning). The resulting large (~109) libraries are then functionally selected for substantially enhanced delivery\, yielding AAVs capable of highly efficient therapeutic gene delivery. Our variants have been effective in both animal models and in 6 human clinical trials to date\, and results from both will be discussed.
URL:https://engineering.wisc.edu/event/cbe-seminar-series-david-schaffer/
LOCATION:Wisconsin
CATEGORIES:Chemical & Biological Engineering,Seminar
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DTSTART;TZID=America/Chicago:20250926T120500
DTEND;TZID=America/Chicago:20250926T125500
DTSTAMP:20260405T160055
CREATED:20250825T193745Z
LAST-MODIFIED:20250915T162031Z
UID:10001274-1758888300-1758891300@engineering.wisc.edu
SUMMARY:Midwest Mechanics Seminar: Professor Daniel Chung
DESCRIPTION:The Mechanics Seminar Series is a weekly seminar given by campus and visiting speakers on topics across the spectrum of mechanics research (solids\, fluids\, and dynamics). Professor Daniel Chung is an Associate Professor at The University of Melbourne.  \n\n\n\nPresentation Title: Fluid mechanics of riblets drag reduction \n\n\n\nAbstract: Riblets are a surface texture composed of tiny ribs applied on aircraft skin to reduce drag\, which saves on fuel\, increases the payload and extends the range. To the fast-moving turbulent air that flows over it\, riblets turn out to be smoother\, generating less skin friction\, than a perfectly flat surface. However\, riblet performance is highly sensitive to their cross-sectional shape and features\, which is bad news because the micron-sized ribs\, imperceptible to the naked eye and challenging to measure even with precision instruments\, are impossible to manufacture and maintain perfectly. Thus\, accurate tolerancing\, not only for manufacture but also for lifetime wear planning and monitoring\, is key to this technology\, requiring predictive capability of the kind that derives from advances in basic understanding. In this regard\, I will present some of the progress we have made in the last few years\, building on decades of research\, on the fluid mechanics of turbulence over riblet surfaces. \n\n\n\nThe support of the Australian Research Council\, Cooperative Research Australia and the U.S. Air Force Office of Scientific Research FA2386-23-1-4071 is gratefully acknowledged. \n\n\n\nBio: Daniel is an associate professor in the Department of Mechanical Engineering at the University of Melbourne. He obtained his bachelor’s degree in engineering and computer science from the University of Melbourne in 2003\, and his PhD in aeronautics from Caltech in 2009. He was a postdoc at the Jet Propulsion Laboratory before joining the University of Melbourne in 2012. Daniel’s research uses computational fluid dynamics\, where he tries to distil turbulent flows into simplified problems and to build physics-based models for prediction. Recently\, he has been interested in understanding and controlling turbulent flow and thermal convection over rough surfaces\, riblets and moving wavy surfaces.
URL:https://engineering.wisc.edu/event/midwest-mechanics-seminar-professor-daniel-chung/
LOCATION:3M Auditorium\, rm 1106 Mechanical Engineering Building\, 1513 University Ave\, Madison\, 53711
CATEGORIES:Mechanical Engineering,Seminar
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