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SUMMARY:BME Seminar Series: Hua Wang\, PhD
DESCRIPTION:Molecular to Systemic Engineering of Immune Cells for Robust Immunotherapy\n\n\n\n\n\n\n\nHua Wang\, PhDAssociate ProfessorDepartment of Materials Science and EngineeringUniversity of Illinois at Urbana-Champaign \n\n\n\nAbstract:Immunotherapy has achieved significant clinical progress for the treatment of cancer and other diseases over the past decade\, but challenges\, including low patient responses\, off-target side effects\, and poor efficacy against solid tumors and autoimmune disorders\, remain. One of our research interests is to understand how immune cells (e.g.\, dendritic cells (DCs)) can be manipulated or engineered using chemistry\, material\, and chemical biology approaches\, in order to develop effective therapies for cancer and other diseases. In this talk\, I will present our recent efforts in molecular\, systemic\, and in situ engineering of DCs and further development of robust cancer vaccines. These include molecules and polymers that can interact with DC membrane and thus activate DCs\, and macroporous materials that can actively recruit and program DCs in situ. I will then conclude my talk with several short stories along the line of metabolic glycan labeling\, another key technology in my lab\, regarding how we made it possible to precisely modulate cells that are historically challenging to engineer. \n\n\n\nPrint PDF
URL:https://engineering.wisc.edu/event/bme-seminar-series-hua-wang-phd/
LOCATION:1003 (Tong Auditorium) Engineering Centers Building\, 1550 Engineering Drive\, Madison\, WI\, 53706\, United States
CATEGORIES:Biomedical Engineering,Seminar
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ORGANIZER;CN="Department of Biomedical Engineering":MAILTO:bmehelp@bme.wisc.edu
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DTSTART;TZID=America/Chicago:20250930T160000
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LAST-MODIFIED:20250909T150710Z
UID:10001288-1759248000-1759251600@engineering.wisc.edu
SUMMARY:CBE Seminar Series: Hal Alper
DESCRIPTION:Hal S. AlperProfessor & Cockrell Family Regents Chair in EngineeringDepartment of Chemical EngineeringUniversity of Texas-AustinAustin\, TX \n\n\n\n\n\n\n\nBeyond the test-tube: metabolic engineering for next-generation applications\n\n\n\nAdvances in metabolic engineering and synthetic biology can enable microbes to produce nearly any organic molecule of interest—from biofuels to biopolymers to pharmaceuticals. While this approach has fueled the industrial biotechnology\, new challenges arise for microbe engineering when considering non-conventional settings. This talk will highlight several unique application areas for metabolic engineering. First\, the use of engineered biology for the degradation of waste products (including plastics and other hydrophobic substrates) will be discussed considering the unique challenges required to consume these non-carbohydrate substrates. Second\, the use of a printable hydrogel system for encapsulating cells will be discussed as a means for both portable cultivation of engineered microbial systems as well as for responsive theranostics. Third\, the engineering of microbial factories for space environments will be discussed. Robust “space-ready” organisms require an understanding of how cells respond to the unique challenges and stressors of space including microgravity\, radiation\, and desiccation. Together\, these efforts demonstrate how to deploy metabolically engineered cells outside of traditional sugar-based bioreactor settings.
URL:https://engineering.wisc.edu/event/cbe-seminar-series-hal-alper/
LOCATION:Wisconsin
CATEGORIES:Chemical & Biological Engineering,Seminar
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DTSTART;TZID=America/Chicago:20251003T120500
DTEND;TZID=America/Chicago:20251003T125500
DTSTAMP:20260405T173705
CREATED:20250825T194253Z
LAST-MODIFIED:20250922T141453Z
UID:10001275-1759493100-1759496100@engineering.wisc.edu
SUMMARY:Mechanics Seminar: Tanmoy Chatterjee
DESCRIPTION:The Mechanics Seminar Series is a weekly seminar given by campus and visiting speakers on topics across the spectrum of mechanics research (solids\, fluids\, and dynamics). Tanmoy Chatterjee is the Lead Research Engineer in Aerodynamics at GE Research Inc.  \n\n\n\nPresentation Title: From Turbulence to Turbines: Exascale CFD in Wind Energy \n\n\n\nAbstract: Wind energy is rapidly expanding in scale\, with individual turbines now exceeding 100-meter blades and offshore farms stretching tens of kilometers. Yet\, predicting their performance and more critically reliability remains a grand challenge of fluid mechanics\, spanning phenomena from centimeter-scale blade boundary layers to kilometer-scale atmospheric flows. This talk explores how exascale computational fluid dynamics (CFD) is transforming our ability to model and design wind energy systems across these scales. I will discuss recent advances in high-fidelity\, turbulent fluid–structure interaction simulations\, and their integration with the Department of Energy’s ExaWind project. Specific examples will include simulations of coastal low-level jets (LLJs) driving wind farm variability\, and the development of data-driven dynamic stall models for next-generation turbine blades. Together\, these efforts highlight how exascale CFD is reshaping our understanding of turbulence\, turbines\, and wind farms — and accelerating innovation in the renewable energy industry. \n\n\n\nBio: Tanmoy Chatterjee is a Lead Research Engineer in Advanced Simulations and Methods at the GE Vernova Advanced Research Center. Prior to joining GE\, he was a postdoctoral researcher at Argonne National Laboratory\, where he developed exascale CFD models using spectral codes for internal combustion engine simulations. He earned his Ph.D. in Mechanical Engineering from Arizona State University\, focusing on turbulence–turbine interactions in large wind farms. \n\n\n\nAt GE Vernova\, Dr. Chatterjee has led the development of high-fidelity exascale CFD–FSI simulations of wind farms and turbine blade-level turbulence\, as well as data-driven reduced-order models for blade vibrations in the regimes of stall-induced and vortex-induced vibrations (SIV/VIV). He has also contributed to advanced controller strategies for mitigating turbine loads under unconventional wind conditions. In addition to his technical contributions\, Dr. Chatterjee has successfully led several GE-internal and government-funded research initiatives\, including projects supporting the DOE-WETO RAAW campaign in collaboration with national laboratories and academic partners.
URL:https://engineering.wisc.edu/event/mechanics-seminar-tanmoy-chatterjee/
LOCATION:3M Auditorium\, rm 1106 Mechanical Engineering Building\, 1513 University Ave\, Madison\, 53711
CATEGORIES:Mechanical Engineering,Seminar
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