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SUMMARY:Bird\, Stewart and Lightfoot Lecture: Daniel Hammer
DESCRIPTION:Room 1610 Engineering Hall \n\n\n\nDaniel HammerAlfred G. and Meta A. Ennis Professor of BioengineeringUniversity of PennsylvaniaPhiladelphia\, PA \n\n\n\nA Tale of Two Motilities\n\n\n\n\n\n\n\nIn the spirit of Bird\, Stewart and Lightfoot\, we have been studying an important problem in transport phenomena\, the biological and bio-inspired motility of cells. \n\n\n\nMotility is important for the functioning of the immune system\, mostly because immune recognition requires molecular transfer by direct cell to cell contact. We have been studying a fascinating form of cell motility in which T-lymphocytes can migrate against the direction of flow\, much like a salmon can swim upstream. Upstream migration is solely due to interactions between a specific lymphocyte receptor\, LFA-1\, and its natural ligand; no other receptor can support upstream migration. Our lab has found that many actively motile cells in the immune system have the ability to migrate upstream. Using CRISPR-Cas9 deletion\, we have identified several molecules in cells that are critical for upstream migration; deletion using Cas9 reverses the direction of migration. We have also made the first traction maps of forces exerted by upstream migrating cells. We found that during upstream migration\, cells maintain their “architecture\,” with active forces in the front and rear\, but the magnitude of the forces greatly increases\, allowing cells to exert sufficient traction to overcome the applied hydrodynamic forces. \n\n\n\nOur laboratory is also interested in making synthetic cells\, or protocells\, that can mimic the behavior of biological cells. In collaboration with Daeyeon Lee at Penn\, we have been making inert capsules using microfluidic assembly that can display motility in solution. By attaching urease to the surface of a capsule\, we can drive autonomous motion of the capsule in a field of urea. We find that asymmetry of the capsule\, in geometry or chemistry\, or both\, greatly enhances capsule motion. In gradients of urea\, our capsules display negative phoresis (move down the gradient). We have preliminary results for the urease-driven motion of Janus capsules\, made by microfluidic assembly from mixtures of phase-separating polymers\, as a function of the geometry of the capsules. \n\n\n\nIn the end\, we draw analogies between our biological and bio-inspired motile systems\, ultimately finding they have little in common.
URL:https://engineering.wisc.edu/event/bird-stewart-and-lightfoot-lecture-daniel-hammer/
LOCATION:Wisconsin
CATEGORIES:Chemical & Biological Engineering,Seminar
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DTSTART;TZID=America/Chicago:20260416T161500
DTEND;TZID=America/Chicago:20260416T170000
DTSTAMP:20260404T170658
CREATED:20260115T171040Z
LAST-MODIFIED:20260401T153438Z
UID:10001409-1776356100-1776358800@engineering.wisc.edu
SUMMARY:ME 150th Celebration: Distinguished Alumni\, Dr. Kelly Senecal
DESCRIPTION:To celebrate 150 years of Mechanical Engineering at the University of Wisconsin – Madison\, the Department of Mechanical Engineering will feature distinguished alumni in mechanical engineering and engineering mechanics who have made a lasting impact on the field. Kelly Senecal\, who received his master’s (’97) and PhD (’00) in mechanical engineering\, is the cofounder of Convergent Science. Kelly also received the 2025 Luminary Award! To learn more about Dr. Kelly Senecal’s experience\, please join us for this installment of our ME 903: Graduate Student Lecture series. \n\n\n\nTitle: From Graduate Research to Global Impact: Building a CFD Company That Challenged Convention \n\n\n\nAbstract: This seminar reflects on the journey from graduate student at the University of Wisconsin–Madison to co-founding a company built on the idea that even established engineering fields can be reimagined. I will share formative experiences from my time at UW–Madison\, the early vision behind building a different kind of CFD company\, and the challenges of pursuing an approach that did not always align with conventional thinking. \n\n\n\nAlong the way\, I will highlight how computational fluid dynamics has grown from a specialized research tool into a technology with global impact across transportation\, energy\, and other critical industries. More importantly\, I will reflect on the lessons learned: that meaningful innovation often requires patience\, resilience\, and the courage to trust fundamentals over trends. \n\n\n\nFor students and researchers\, the message is simple: protect your curiosity\, question assumptions\, and be willing to take the long path. The most impactful ideas are not always the most popular at the start\, `but they are the ones worth pursuing. \n\n\n\nBio: Dr. Kelly Senecal is a co-founder of Convergent Science\, an industry-leading computational fluid dynamics software company. He is a visiting professor at the University of Oxford and a co-founder and director of the Computational Chemistry Consortium (C3). Dr. Senecal is a Fellow of the Society of Automotive Engineers (SAE)\, the American Society of Mechanical Engineers (ASME)\, and the Combustion Institute (CI). He is the Chair of the executive committee of the ASME Transportation Systems Division and a member of the board of directors of the Combustion Institute. Recent accolades include the 2019 ASME ICE Award\, the 2023 SAE John Johnson Diesel Engine Research Medal\, the 2023 ASME Dedicated Service Award\, the 2025 ASME Soichiro Honda Medal\, and the 2025 University of Wisconsin Alumni Association Luminary Award. \n\n\n\nDr. Senecal has long been an advocate of creating cleaner propulsion systems\, with a particular focus on using CFD and HPC to enable faster design. Starting with his TEDx talk in late 2016\, he has promoted a diverse mix of transportation technologies through invited talks\, articles\, and social media. Dr. Senecal is co-author of the book Racing Toward Zero: The Untold Story of Driving Green\, winner of the 2022 Independent Press Award for Environment.
URL:https://engineering.wisc.edu/event/me-903-graduate-seminar-dr-kelly-senecal/
LOCATION:3M Auditorium\, rm 1106 Mechanical Engineering Building\, 1513 University Ave\, Madison\, 53711
CATEGORIES:Mechanical Engineering,Seminar
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DTSTART;TZID=America/Chicago:20260417T120000
DTEND;TZID=America/Chicago:20260417T130000
DTSTAMP:20260404T170658
CREATED:20260120T213231Z
LAST-MODIFIED:20260123T142322Z
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SUMMARY:Midwest Mechanics Seminar: Professor Laura de Lorenzis
DESCRIPTION:The Mechanics Seminar Series is a weekly seminar given by campus and visiting speakers on topics across the spectrum of mechanics research (solids\, fluids\, and dynamics). This specific seminar is hosted in conjunction with the Midwest Mechanics Seminar Series. Professor Laura de Lorenzis is a professor at Institute for Mechanical Systems – Zurich.
URL:https://engineering.wisc.edu/event/midwest-mechanics-seminar-professor-laura-de-lorenzis/
LOCATION:Engineering Research Building\, Room 106\, 1500 Engineering Dr.\, Madison\, Wisconsin\, 53706
CATEGORIES:Mechanical Engineering,Seminar
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