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X-WR-CALNAME:College of Engineering - University of Wisconsin-Madison
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X-WR-CALDESC:Events for College of Engineering - University of Wisconsin-Madison
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DTSTART;TZID=America/Chicago:20250923T160000
DTEND;TZID=America/Chicago:20250923T170000
DTSTAMP:20250827T163458Z
CREATED:20250827T163455Z
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UID:10001287-1758643200-1758646800@engineering.wisc.edu
SUMMARY:CBE Seminar Series: David Schaffer
DESCRIPTION:David SchafferDepartment of Chemical and Biomolecular EngineeringUniversity of California-Berkeley Berkeley\, CA \n\n\n\n\n\n\n\nDirected Evolution of New AAV Vectors for Clinical Gene Therapy\n\n\n\nGene therapy has experienced an increasing number of successful human clinical trials\, leading to 6 FDA approved products using delivery vectors based on adeno-associated viruses (AAV). These successes were possible due to the identification of specific disease targets for which natural variants of AAV were sufficient. However\, vectors face a number of barriers and shortcomings that preclude their extension to most human diseases\, including limited delivery efficiency to target cells\, pre-existing antibodies against AAVs\, suboptimal biodistribution\, limited spread within tissues\, and/or an inability to target delivery to specific cells. These barriers are not surprising\, since the parent viruses upon which vectors are based were not evolved by nature for our convenience to use as human therapeutics. Unfortunately\, for most applications\, there is insufficient mechanistic knowledge of underlying virus structure-function relationships to empower rational design improvements. As an alternative\, for over two decades we have been implementing directed evolution–the iterative genetic diversification of the viral genome and functional selection for desired properties–to engineer highly optimized\, next generation AAV variants for efficient and targeted delivery to any cell or tissue target. We have genetically diversified AAV using a broad range of approaches from fully random (e.g. error prone PCR) to computationally guided (e.g. by machine learning). The resulting large (~109) libraries are then functionally selected for substantially enhanced delivery\, yielding AAVs capable of highly efficient therapeutic gene delivery. Our variants have been effective in both animal models and in 6 human clinical trials to date\, and results from both will be discussed.
URL:https://engineering.wisc.edu/event/cbe-seminar-series-david-schaffer/
CATEGORIES:Chemical & Biological Engineering,Seminar
ATTACH;FMTTYPE=image/jpeg:https://engineering.wisc.edu/wp-content/uploads/2023/02/2023_CBE-sem-series-web-header-scaled.webp
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DTSTART;TZID=America/Chicago:20250922T120000
DTEND;TZID=America/Chicago:20250922T130000
DTSTAMP:20250910T203228Z
CREATED:20250827T170410Z
LAST-MODIFIED:20250910T203228Z
UID:10001292-1758542400-1758546000@engineering.wisc.edu
SUMMARY:BME Seminar Series: Marty Pagel\, PhD
DESCRIPTION:Molecular Imaging of the Tumor Microenvironment\n\n\n\n\n\n\n\nMarty Pagel\, PhDProfessorDepartment of Medical PhysicsDepartment of RadiologyUniversity of Wisconsin-Madison \n\n\n\nAbstract:Tumor acidosis\, hypoxia\, and vascular perfusion are well-known characteristics of the tumor microenvironment. We have developed MRI\, MR Fingerprinting\, PET/MRI\, electron paramagnetic resonance imaging (EPRI)\, and photoacoustic imaging (PAI) to quantitatively measure extracellular pH\, oxygenation\, and pharmacokinetic transport rates in solid tumors. We apply these molecular imaging methods to preclinical tumor models\, and we have translated some of our methods to evaluate patients who have cancer. We are especially focused on employing molecular imaging to predict treatment effect before starting therapy\, and to evaluate the early response to treatment\, during evaluations of chemotherapy\, radiotherapy and immunotherapy. This presentation will discuss a variety of molecular imaging methods and research applications\, and also discuss a value proposition for molecular imaging. \n\n\n\nPrint PDF
URL:https://engineering.wisc.edu/event/bme-seminar-series-marty-pagel-phd/
LOCATION:1003 (Tong Auditorium) Engineering Centers Building\, 1550 Engineering Drive\, Madison\, WI\, 53706\, United States
CATEGORIES:Biomedical Engineering,Seminar
ATTACH;FMTTYPE=image/jpeg:https://engineering.wisc.edu/wp-content/uploads/2024/11/Seminar-Graphic-Fall2024-1.avif
ORGANIZER;CN="Department of Biomedical Engineering":MAILTO:bmehelp@bme.wisc.edu
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DTSTART;TZID=America/Chicago:20250922T000000
DTEND;TZID=America/Chicago:20250922T235959
DTSTAMP:20250916T194726Z
CREATED:20250916T194724Z
LAST-MODIFIED:20250916T194726Z
UID:10001330-1758499200-1758585599@engineering.wisc.edu
SUMMARY:ISyE - AI in Industrial Engineering
DESCRIPTION:Join IISE for a crash course on AI and how it relates to our major in the workforce.  \n\n\n\n \n\n\n\nMore info to come soon!
URL:https://engineering.wisc.edu/event/isye-ai-in-industrial-engineering/
CATEGORIES:Industrial & Systems Engineering
ATTACH;FMTTYPE=image/jpeg:https://engineering.wisc.edu/wp-content/uploads/2024/09/Student-Org-EVent-scaled.avif
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BEGIN:VEVENT
DTSTART;TZID=America/Chicago:20250919T170000
DTEND;TZID=America/Chicago:20250919T220000
DTSTAMP:20250916T195821Z
CREATED:20250916T195625Z
LAST-MODIFIED:20250916T195821Z
UID:10001331-1758301200-1758319200@engineering.wisc.edu
SUMMARY:ISyE - Terrace Hangout!
DESCRIPTION:Join the graduate student orgs from ISyE for a night on the Terrace. \n\n\n\n \n\n\n\nStudents from across ISyE are encouraged to join their peers from INFORMS\, HFES and SME for an evening on the terrace. This is a chance to catch up\, meet old and new faces\, and simply relax by the lake.
URL:https://engineering.wisc.edu/event/isye-terrace-hangout/
LOCATION:Memorial Union Terrace\, 800 Langdon St\, Madison\, Wisconsin\, 53706
CATEGORIES:Industrial & Systems Engineering
ATTACH;FMTTYPE=image/jpeg:https://engineering.wisc.edu/wp-content/uploads/2025/09/terrace2.avif
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DTSTART;TZID=America/Chicago:20250919T120500
DTEND;TZID=America/Chicago:20250919T125500
DTSTAMP:20250915T161922Z
CREATED:20250825T193504Z
LAST-MODIFIED:20250915T161922Z
UID:10001273-1758283500-1758286500@engineering.wisc.edu
SUMMARY:Mechanics Seminar: Professor Matthew Brake
DESCRIPTION:The Mechanics Seminar Series is a weekly seminar given by campus and visiting speakers on topics across the spectrum of mechanics research (solids\, fluids\, and dynamics). Professor Matthew Brake is an Associate Professor at Rice University.  \n\n\n\nPresentation Title: Videographic Modal Analysis \n\n\n\nAbstract: Experimental modal analysis is a classical tool that has formed the basis of modern vibration testing and qualification. Despite this\, the process of experimental modal analysis is largely reliant upon techniques from over 60 years ago. Typical experiments of large structures can take months of planning and setup\, and require thousands of channels of accelerometer data. To lower the cost and time associated with vibration testing\, Videographic Modal Analysis (VMA) combines recent advances in data science\, image processing\, and traditional modal analysis concepts. First\, natural frequencies are identified from videos of an experiment using a deep learning algorithm. Once these frequencies are identified\, optical flow\, phase-based motion magnification\, and edge detection techniques are automatically applied to quantitatively characterize the mode shapes of the structure. Without instrumentation\, we can now identify mode shapes and natural frequencies of arbitrary structures in real-world settings (not just beams vibrating in labs!). This talk will present the science behind VMA and demonstrate its applicability. \n\n\n\nBio: Prof. Brake started at Rice University in 2016 after working at Sandia National Laboratories for nine years. Prior to Sandia\, Prof. Brake graduated from Carnegie Mellon University in 2007. Prof. Brake has been elected to several leadership positions\, including as the director of the International Committee on Joint Mechanics\, the chair of the Nonlinear Dynamics Technical Division of SEM\, and the chair of the ASME Technical Committee on Vibration and Sound. He is a recipient of the 2012 Presidential Early Career Award for Scientists and Engineers\, the 2018 C.D. Mote Jr Early Career Award\, and the National Science Foundation Career Award. His primary research interests are in data-driven experimentation\, multi-scale and multi-physics modeling\, vibration\, tribology\, uncertainty propagation\, structural health monitoring\, and nonlinear dynamics.
URL:https://engineering.wisc.edu/event/mechanics-seminar-professor-matthew-brake/
LOCATION:3M Auditorium\, rm 1106 Mechanical Engineering Building\, 1513 University Ave\, Madison\, 53711
CATEGORIES:Mechanical Engineering,Seminar
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