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DTSTART;TZID=America/Chicago:20251124T120000
DTEND;TZID=America/Chicago:20251124T130000
DTSTAMP:20260421T052203
CREATED:20250827T171853Z
LAST-MODIFIED:20251110T205535Z
UID:10001299-1763985600-1763989200@engineering.wisc.edu
SUMMARY:BME Seminar Series: Julien Berro\, PhD
DESCRIPTION:Fantastic forces and where to find them\n\n\n\n\n\n\n\nJulien Berro\, PhDAssociate Professor of Molecular Biophysics and Biochemistry\, and of Cell BiologySchool of MedicineYale University \n\n\n\nAbstract:Mechanical forces are central to countless biological processes in health and disease. However\, despite their ubiquity and importance in cellular processes\, our understanding of biomechanical forces lags far behind our understanding of the underlying biochemistry. Studying forces within cells is difficult because tools and approaches to directly probe forces at the molecular level are scarce\, difficult to use or have limited applications. In this seminar\, I will present approaches based on quantitative microscopy\, mathematical modeling and molecular force sensor engineering that my lab has developed to readily measure biophysical quantities so far impossible or difficult to measure in vivo. Using clathrin-mediated endocytosis as a model system\, I will show how these methods have uncovered new molecular mechanisms of force production\, force transmission and force sensing by the actin cytoskeleton. \n\n\n\nPrint PDF
URL:https://engineering.wisc.edu/event/bme-seminar-series-julien-berro-phd/
LOCATION:1003 (Tong Auditorium) Engineering Centers Building\, 1550 Engineering Drive\, Madison\, WI\, 53706\, United States
CATEGORIES:Biomedical Engineering,Seminar
ATTACH;FMTTYPE=image/jpeg:https://engineering.wisc.edu/wp-content/uploads/2024/11/Seminar-Graphic-Fall2024-1.avif
ORGANIZER;CN="Department of Biomedical Engineering":MAILTO:bmehelp@bme.wisc.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Chicago:20251117T120000
DTEND;TZID=America/Chicago:20251117T130000
DTSTAMP:20260421T052203
CREATED:20250827T171457Z
LAST-MODIFIED:20251110T204032Z
UID:10001298-1763380800-1763384400@engineering.wisc.edu
SUMMARY:BME Seminar Series: Sara McBride-Gagyi\, PhD
DESCRIPTION:Failing Fabulously: Vogue Challenging Niche Large-Scale Bone Repair Research Missteps into Broad Impact Innovations\n\n\n\n\n\n\n\nSara McBride-Gagyi\, PhDAssistant ProfessorDepartment of Biomedical EngineeringThe Ohio State University \n\n\n\nAbstract:Research rarely unfolds exactly as planned. Despite careful preparation and well-designed protocols\, unexpected outcomes — and outright failures — are an inevitable part of experimental science and engineering. Yet these challenges are seldom shared publicly\, leaving many trainees and early-career researchers feeling isolated or discouraged when things go awry. \n\n\n\nIn this talk\, Dr. Sara McBride-Gagyi will share two recent projects from her lab related to her larger research on bone regeneration that faced significant\, unforeseen setbacks — challenges that could easily have been dismissed as fatal failures that wasted valuable time and resources. Instead\, through creative problem-solving and critical re-evaluation\, her team turned these obstacles into opportunities\, ultimately generating results and innovations more impactful than the original aims. \n\n\n\nDr. McBride-Gagyi will walk through each project chronologically\, highlighting the engineering design pivots\, decision-making processes\, and lessons learned along the way. She will conclude with a discussion of how these experiences are being reframed for publication and dissemination — underscoring the value of transparency\, adaptability\, and perseverance in the scientific process. \n\n\n\nPrint PDF
URL:https://engineering.wisc.edu/event/bme-seminar-series-sara-mcbride-gagyi-phd/
LOCATION:1003 (Tong Auditorium) Engineering Centers Building\, 1550 Engineering Drive\, Madison\, WI\, 53706\, United States
CATEGORIES:Biomedical Engineering,Seminar
ATTACH;FMTTYPE=image/jpeg:https://engineering.wisc.edu/wp-content/uploads/2024/11/Seminar-Graphic-Fall2024-1.avif
ORGANIZER;CN="Department of Biomedical Engineering":MAILTO:bmehelp@bme.wisc.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Chicago:20251103T120000
DTEND;TZID=America/Chicago:20251103T130000
DTSTAMP:20260421T052203
CREATED:20250827T171205Z
LAST-MODIFIED:20251028T231824Z
UID:10001297-1762171200-1762174800@engineering.wisc.edu
SUMMARY:BME Seminar Series: EnsoData
DESCRIPTION:The Entrepreneurial Journey of EnsoData Co-Founders\n\n\n\nChris Fernandez BMEBS’14\, MS’15; Ensodata Co-founder\, Executive Chairman and Chief Research OfficerNick Glattard BMEBS’14\, MS’15; EnsoData Co-founder and Chief Technology Officer \n\n\n\nHear firsthand how two BME alumni turned a bold idea into a nationally recognized startup. \n\n\n\nNick Glattard (BMEBS ’14\, MS ’15) and Chris Fernandez (BMEBS ’14\, MS ’15)\, Cofounders of EnsoData\, will share their remarkable journey from UW–Madison biomedical engineering students to leading a cutting-edge company that’s transforming sleep medicine. Their presentation will delve into the challenges and triumphs of building EnsoData. \n\n\n\nPrint PDF
URL:https://engineering.wisc.edu/event/bme-seminar-series-3/
LOCATION:1003 (Tong Auditorium) Engineering Centers Building\, 1550 Engineering Drive\, Madison\, WI\, 53706\, United States
CATEGORIES:Biomedical Engineering,Seminar
ATTACH;FMTTYPE=image/jpeg:https://engineering.wisc.edu/wp-content/uploads/2024/11/Seminar-Graphic-Fall2024-1.avif
ORGANIZER;CN="Department of Biomedical Engineering":MAILTO:bmehelp@bme.wisc.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Chicago:20251027T120000
DTEND;TZID=America/Chicago:20251027T130000
DTSTAMP:20260421T052203
CREATED:20250827T171128Z
LAST-MODIFIED:20251013T212823Z
UID:10001295-1761566400-1761570000@engineering.wisc.edu
SUMMARY:BME Seminar Series: Keefe Manning\, PhD
DESCRIPTION:Predicting Thrombus Formation\, Deformation\, and Embolization: A Look at Devices\, Stroke\, and Deep Vein Thrombosis\n\n\n\n\n\n\n\nKeefe Manning\, PhDProfessor of Biomedical Engineering and SurgeryDepartment of Biomedical EngineeringPennsylvania State University \n\n\n\nAbstract:Thrombosis remains a significant clinical issue manifesting in heart attacks and strokes but also challenges the success of cardiovascular devices. Given the complex process associated with thrombosis\, developing accurate computational models is difficult as validation needs to occur over a range of flow and surface interactions and at different temporal and spatial scales. Thrombi are particularly interesting because of their inherent heterogeneity. Leveraging canonical experiments that acquire a breadth of data will be crucial to validate any computational model\, but do these experiments accurately represent how thrombi form\, deform\, and embolize in the context of devices\, stroke\, and deep vein thrombosis? This presentation will cover the development and experimental validation of our computational models in these areas and the complications posed with blood experiments. \n\n\n\nPrint PDF
URL:https://engineering.wisc.edu/event/bme-seminar-series-keefe-manning-phd/
LOCATION:1003 (Tong Auditorium) Engineering Centers Building\, 1550 Engineering Drive\, Madison\, WI\, 53706\, United States
CATEGORIES:Biomedical Engineering,Seminar
ATTACH;FMTTYPE=image/jpeg:https://engineering.wisc.edu/wp-content/uploads/2024/11/Seminar-Graphic-Fall2024-1.avif
ORGANIZER;CN="Department of Biomedical Engineering":MAILTO:bmehelp@bme.wisc.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Chicago:20251020T120000
DTEND;TZID=America/Chicago:20251020T130000
DTSTAMP:20260421T052203
CREATED:20250827T170721Z
LAST-MODIFIED:20251013T212556Z
UID:10001294-1760961600-1760965200@engineering.wisc.edu
SUMMARY:BME Seminar Series: Susan Leggett\, PhD
DESCRIPTION:Engineering Tumor Microenvironments on a Chip to Model Early Events in Breast and Ovarian Cancer Metastasis\n\n\n\n\n\n\n\nSusan Leggett\, PhDAssistant ProfessorDepartment of BioengineeringUniversity of Illinois at Urbana-Champaign \n\n\n\nAbstract:The tumor microenvironment is a dynamic and multifaceted ecosystem in which biochemical and mechanical cues jointly regulate cell behavior\, tumor heterogeneity\, and disease progression. My lab develops engineered “tumor-on-a-chip” systems to reconstruct the 3D tumor microenvironment and dissect how cell-cell interactions\, fluid flow\, and interfacial mechanics influence early metastatic events. In this talk\, I will first introduce our approach for the rapid and accessible fabrication of organ-on-a-chip devices using epoxy-coated 3D printed molds. This workflow enables the generation of high-fidelity\, biocompatible PDMS-based devices in a scalable\, reproducible\, and imaging-compatible format. I will then discuss how we are leveraging this technology to reverse-engineer solid breast tumors composed of heterogeneous cancer cell and immune cell subpopulations\, including macrophages\, to model how tumor-immune interactions shape cell plasticity and collective invasion. Finally\, I will present our novel peritoneal cavity-on-a-chip\, designed to mimic the primary route of ovarian cancer spread. In this model\, individual ovarian cancer cells and clusters can be injected into fluid-filled peritoneal cavities to emulate circulating tumor cells that shed from the ovary during disease progression. Using live-cell imaging\, we examine how these cells interact with\, and infiltrate\, the surrounding mesothelium to initiate metastatic colonization. Together\, these approaches establish versatile experimental platforms to study dynamic cell and tissue-level behaviors\, providing new strategies to model\, predict\, and ultimately control metastatic progression. \n\n\n\nPrint PDF
URL:https://engineering.wisc.edu/event/bme-seminar-series-susan-leggett-phd/
LOCATION:1003 (Tong Auditorium) Engineering Centers Building\, 1550 Engineering Drive\, Madison\, WI\, 53706\, United States
CATEGORIES:Biomedical Engineering,Seminar
ATTACH;FMTTYPE=image/jpeg:https://engineering.wisc.edu/wp-content/uploads/2024/11/Seminar-Graphic-Fall2024-1.avif
ORGANIZER;CN="Department of Biomedical Engineering":MAILTO:bmehelp@bme.wisc.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Chicago:20251006T120000
DTEND;TZID=America/Chicago:20251006T130000
DTSTAMP:20260421T052203
CREATED:20250827T170456Z
LAST-MODIFIED:20250929T204758Z
UID:10001293-1759752000-1759755600@engineering.wisc.edu
SUMMARY:BME Seminar Series: From Campus to Career: Maximizing Experiences for Industry Readiness
DESCRIPTION:Abstract: Universities are organized primarily by departments\, but industry is organized by function: research\, design\, regulatory\, quality assurance\, sales\, marketing. Having some knowledge of this structure ahead of time will help you select and approach classes in ways more likely to have you end up where you want to be.Fortunately\, the UW-Madison also has many opportunities that let you “try on” an industrial career ahead of time. These opportunities vary in duration from hours to months. As you start to invest in these channels\, you will be more likely to benefit from the serendipity that the breath of expertise present at UW-Madison naturally provides.This seminar will feature three individuals in a conversational format who will discuss how they used these channels to supplement their coursework and research to build industrial success. While all three of these individuals eventually earned PhDs\, the topics and approaches discussed are equally applicable to MS students. \n\n\n\nSpeakers (L to R):Professor Chris Brace\, PhD; UW BME Vice Chair; Co-founder\, NeuWave MedicalJustin Koepsel\, PhD\, MBA; UW BME MS’08\, PhD’12; Senior Director of Commercial Operations at Catalent BiologicsTom Lilieholm\, PhD’24; Co-founder and Director of Neuroimaging ImgGyd \n\n\n\n\n\n\n\nPrint PDF
URL:https://engineering.wisc.edu/event/bme-seminar-series-2/
LOCATION:1003 (Tong Auditorium) Engineering Centers Building\, 1550 Engineering Drive\, Madison\, WI\, 53706\, United States
CATEGORIES:Biomedical Engineering,Seminar
ATTACH;FMTTYPE=image/jpeg:https://engineering.wisc.edu/wp-content/uploads/2024/11/Seminar-Graphic-Fall2024-1.avif
ORGANIZER;CN="Department of Biomedical Engineering":MAILTO:bmehelp@bme.wisc.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Chicago:20250929T120000
DTEND;TZID=America/Chicago:20250929T130000
DTSTAMP:20260421T052203
CREATED:20250827T170251Z
LAST-MODIFIED:20250910T203342Z
UID:10001291-1759147200-1759150800@engineering.wisc.edu
SUMMARY:BME Seminar Series: Hua Wang\, PhD
DESCRIPTION:Molecular to Systemic Engineering of Immune Cells for Robust Immunotherapy\n\n\n\n\n\n\n\nHua Wang\, PhDAssociate ProfessorDepartment of Materials Science and EngineeringUniversity of Illinois at Urbana-Champaign \n\n\n\nAbstract:Immunotherapy has achieved significant clinical progress for the treatment of cancer and other diseases over the past decade\, but challenges\, including low patient responses\, off-target side effects\, and poor efficacy against solid tumors and autoimmune disorders\, remain. One of our research interests is to understand how immune cells (e.g.\, dendritic cells (DCs)) can be manipulated or engineered using chemistry\, material\, and chemical biology approaches\, in order to develop effective therapies for cancer and other diseases. In this talk\, I will present our recent efforts in molecular\, systemic\, and in situ engineering of DCs and further development of robust cancer vaccines. These include molecules and polymers that can interact with DC membrane and thus activate DCs\, and macroporous materials that can actively recruit and program DCs in situ. I will then conclude my talk with several short stories along the line of metabolic glycan labeling\, another key technology in my lab\, regarding how we made it possible to precisely modulate cells that are historically challenging to engineer. \n\n\n\nPrint PDF
URL:https://engineering.wisc.edu/event/bme-seminar-series-hua-wang-phd/
LOCATION:1003 (Tong Auditorium) Engineering Centers Building\, 1550 Engineering Drive\, Madison\, WI\, 53706\, United States
CATEGORIES:Biomedical Engineering,Seminar
ATTACH;FMTTYPE=image/jpeg:https://engineering.wisc.edu/wp-content/uploads/2024/11/Seminar-Graphic-Fall2024-1.avif
ORGANIZER;CN="Department of Biomedical Engineering":MAILTO:bmehelp@bme.wisc.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Chicago:20250922T120000
DTEND;TZID=America/Chicago:20250922T130000
DTSTAMP:20260421T052203
CREATED:20250827T170410Z
LAST-MODIFIED:20250910T203228Z
UID:10001292-1758542400-1758546000@engineering.wisc.edu
SUMMARY:BME Seminar Series: Marty Pagel\, PhD
DESCRIPTION:Molecular Imaging of the Tumor Microenvironment\n\n\n\n\n\n\n\nMarty Pagel\, PhDProfessorDepartment of Medical PhysicsDepartment of RadiologyUniversity of Wisconsin-Madison \n\n\n\nAbstract:Tumor acidosis\, hypoxia\, and vascular perfusion are well-known characteristics of the tumor microenvironment. We have developed MRI\, MR Fingerprinting\, PET/MRI\, electron paramagnetic resonance imaging (EPRI)\, and photoacoustic imaging (PAI) to quantitatively measure extracellular pH\, oxygenation\, and pharmacokinetic transport rates in solid tumors. We apply these molecular imaging methods to preclinical tumor models\, and we have translated some of our methods to evaluate patients who have cancer. We are especially focused on employing molecular imaging to predict treatment effect before starting therapy\, and to evaluate the early response to treatment\, during evaluations of chemotherapy\, radiotherapy and immunotherapy. This presentation will discuss a variety of molecular imaging methods and research applications\, and also discuss a value proposition for molecular imaging. \n\n\n\nPrint PDF
URL:https://engineering.wisc.edu/event/bme-seminar-series-marty-pagel-phd/
LOCATION:1003 (Tong Auditorium) Engineering Centers Building\, 1550 Engineering Drive\, Madison\, WI\, 53706\, United States
CATEGORIES:Biomedical Engineering,Seminar
ATTACH;FMTTYPE=image/jpeg:https://engineering.wisc.edu/wp-content/uploads/2024/11/Seminar-Graphic-Fall2024-1.avif
ORGANIZER;CN="Department of Biomedical Engineering":MAILTO:bmehelp@bme.wisc.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Chicago:20250915T120000
DTEND;TZID=America/Chicago:20250915T130000
DTSTAMP:20260421T052203
CREATED:20250827T165905Z
LAST-MODIFIED:20250905T181419Z
UID:10001290-1757937600-1757941200@engineering.wisc.edu
SUMMARY:BME Seminar Series: Allen Garner PhD
DESCRIPTION:Electrical Manipulation of Biological Cells: Models and Applications\n\n\n\n\n\n\n\nAllen Garner\, PhD\, PEProfessor\, Graduate Program ChairSchool of Nuclear EngineeringPurdue University \n\n\n\nElectric waveforms\, including electric pulses (EPs) and alternating current (AC) fields\, such as radiofrequency and high-power microwaves\, can induce deleterious or beneficial effects that require additional characterization. We combine thermal models with the Smoluchowski equation to assess the interactions of EP and AC waveforms with biological cells. We further develop a computationally efficient model based on the asymptotic Smoluchowski to screen biological response over seven orders of magnitude of pulse duration with excellent agreement between simulated electroporation and experimental observations. Applications in microorganism inactivation\, natural products for cancer therapy\, platelet activation\, and stem cell stimulation will be discussed. \n\n\n\nPrint PDF
URL:https://engineering.wisc.edu/event/bme-seminar-series-allen-garner-phd/
LOCATION:1003 (Tong Auditorium) Engineering Centers Building\, 1550 Engineering Drive\, Madison\, WI\, 53706\, United States
CATEGORIES:Biomedical Engineering,Seminar
ATTACH;FMTTYPE=image/jpeg:https://engineering.wisc.edu/wp-content/uploads/2024/11/Seminar-Graphic-Fall2024-1.avif
ORGANIZER;CN="Department of Biomedical Engineering":MAILTO:bmehelp@bme.wisc.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Chicago:20250428T120000
DTEND;TZID=America/Chicago:20250428T130000
DTSTAMP:20260421T052203
CREATED:20250204T172651Z
LAST-MODIFIED:20250407T164436Z
UID:10001149-1745841600-1745845200@engineering.wisc.edu
SUMMARY:BME Seminar Series: Jessica Wagenseil\, PhD
DESCRIPTION:Biomechanics of Thoracic Aortic Aneurysms\n\n\n\n\n\n\n\nJessica Wagenseil\, DScProfessor\, Mechanical Engineering and Materials ScienceVice Dean for Faculty AdvancementMcKelvey School of EngineeringWashington University \n\n\n\nAbstract:Thoracic aortic aneurysms are a dilation of the aortic wall that can be asymptomatic for many years until they dissect or rupture. Dissection or rupture is associated with a high mortality rate. Surgical replacement is the current treatment standard and is performed when the aortic aneurysm reaches a specified size or growth rate. However\, many aortic aneurysms fail before reaching these thresholds and many pass the thresholds without failing. We are interested in predicting how the aneurysm will grow\, remodel\, and fail in response to mechanical stimuli using mouse models of human aneurysmal disease. Data will be presented from our work on biomechanical metrics associated with aneurysms\, correlations between mechanical changes and biochemical signaling\, growth and remodeling predictions of aneurysm progression\, fluid-solid structure interaction modeling of aneurysm biomechanics and failure\, and transmural fluid and solid transport\, as possible contributions to aneurysmal disease. \n\n\n\nPrint PDF
URL:https://engineering.wisc.edu/event/bme-seminar-series-jessica-wagenseil-phd/
LOCATION:1003 (Tong Auditorium) Engineering Centers Building\, 1550 Engineering Drive\, Madison\, WI\, 53706\, United States
CATEGORIES:Biomedical Engineering,Seminar
ATTACH;FMTTYPE=image/jpeg:https://engineering.wisc.edu/wp-content/uploads/2024/11/Seminar-Graphic-Fall2024-1.avif
ORGANIZER;CN="Department of Biomedical Engineering":MAILTO:bmehelp@bme.wisc.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Chicago:20250421T120000
DTEND;TZID=America/Chicago:20250421T130000
DTSTAMP:20260421T052203
CREATED:20250204T172623Z
LAST-MODIFIED:20250407T164208Z
UID:10001148-1745236800-1745240400@engineering.wisc.edu
SUMMARY:BME Seminar Series: Alan Jassanof\, PhD
DESCRIPTION:Analyzing Brain-Wide Function Using New Molecular Imaging Tools\n\n\n\n\n\n\n\nAlan Jasanoff\, PhDProfessor of Biological Engineering and Brain and Cognitive SciencesMassachusetts Institute of Technology \n\n\n\nAbstract:Behavior and cognition depend on the integrated action of neural structures and populations distributed throughout the brain. Deciphering mechanisms by which this takes this place is both a tremendous scientific problem and a major engineering challenge\, because of the need to establish suitable measurement technologies. We are creating a set of molecular imaging tools that enable multiregional neural processing to be studied at a brain-wide scale in rodents and nonhuman primates. Here we will describe how a novel genetically encoded activity reporter we have engineered enables information flow in virally labeled neural circuitry to be monitored by fMRI. Using the reporter to perform functional imaging of synaptically defined cell populations in the rat somatosensory system\, we show how activity is transformed within brain regions to yield characteristics specific to distinct output projections. We also show how this approach enables regional activity phenomena to be modeled in terms of inputs\, in a paradigm that we are extending to address circuit-level origins of functional specialization in marmoset brains. In the second part of the talk\, we will discuss how some of our MRI tools now enable the detection of optical reporters in deep neural tissue. We use novel imaging probes to detect luminescent proteins\, yielding a hybrid optical/MRI noninvasive imaging modality that surpasses limitations of conventional methods. This work demonstrates the possibility of investigating diverse brain-wide processing phenomena using advanced molecular neuroimaging methods. \n\n\n\nPrint PDF
URL:https://engineering.wisc.edu/event/bme-seminar-series-alan-jassanof-phd/
LOCATION:1003 (Tong Auditorium) Engineering Centers Building\, 1550 Engineering Drive\, Madison\, WI\, 53706\, United States
CATEGORIES:Biomedical Engineering,Seminar
ATTACH;FMTTYPE=image/jpeg:https://engineering.wisc.edu/wp-content/uploads/2024/11/Seminar-Graphic-Fall2024-1.avif
ORGANIZER;CN="Department of Biomedical Engineering":MAILTO:bmehelp@bme.wisc.edu
END:VEVENT
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