My research focuses on enhancing the damage tolerance of active materials for the modern energy industry (e.g., applications ranging from nuclear power plants to batteries), whose microstructures dynamically evolve during service and are subject to significant internal stresses. We engineer imperfections in materials to promote relatively benign damage while preventing the development of catastrophic damage, such as helium embrittlement in irradiated metals for nuclear reactors and electrochemo-mechanical degradation of solid electrolytes. To this end, our work integrates high-throughput atomistic modeling with autonomous materials synthesis and in operando microscopy and diffractometry. Through these efforts, we aim to enable both economically and environmentally sustainable energy infrastructures.