Biomedical Engineering

Metabolic Adaptations of Drug-Tolerant Persister Cells Mehmet A Orman, PhDAssociate ProfessorChemical and Biomolecular Engineering DepartmentUniversity of Houston Abstract:My research focuses on understanding drug-tolerant phenotypes, particularly persister cells, in both prokaryotic and eukaryotic systems. Persister cells are temporarily tolerant to drugs and contribute significantly to disease recurrence. We investigate their molecular makeup, including metabolite profiles, RNA...

Artificial intelligence for state-of-the-art gene therapy Jacob Witten, PhDPostdoctoral FellowAnderson LabMassachusetts Institute of Technology Abstract:Lipid nanoparticles (LNPs) for RNA delivery have exploded onto the biomedical research scene with the success of mRNA vaccines for COVID-19. In addition to their promise as mRNA vaccines for infectious disease and cancer, LNPs have the potential to treat or...

Engineering multistate trackable cells for smart precision therapeutics Arash Farhadi, PhDPostdoctoral ScholarVoigt LabMassachusetts Institute of Technology Abstract:The engineering of immune cells and microbes into living therapeutics is emerging as a powerful approach for treating many diseases. However, two key challenges must be addressed to unlock the full potential of living therapeutics: intricately programming cells to...

Understanding Aging at Multi-scale Using Explainable AI Wei QiuPhD CandidateComputer Science and Engineering DepartmentUniversity of Washington Abstract:As human lifespans continue to extend, it becomes increasingly critical to understand the aging...

Mapping cellular responses to perturbations with dynamic computational imaging and AI Shalin Mehta, PhDPlatform LeaderComputational MicroscopyChan Zuckerberg Biohub co-sponsors: Morgridge Institute for Research and the Center for Quantitative Cellular Imaging Abstract:Discovery of biological mechanisms, drugs, and therapeutics is being accelerated by image-based profiling of cellular responses to perturbations. In this seminar, I will discuss our...

The Death and Re-Birth of the Intervertebral Disc Cell Lori A. Setton, PhDLopata Distinguished Professor and Chair of Biomedical EngineeringMcKelvey School of Engineering, Washington University in St. Louis Corrine Bahr...