Seminar

Using Bottlebrush Polymers to Tackle Challenges in Drug Delivery and Tissue Engineering Monica Ohnsorg, PhDPostdoctoral FellowDepartment of Chemical and Biological EngineeringBioFrontiers InstituteUniversity of Colorado Boulder Abstract:Macromolecular design can be a powerful tool to improve the efficacy of clinical therapeutics and develop biomaterials to support in vitro human cell-based models. In this talk, I will discuss...

Bridging Molecular and Functional Understandings of Cells with Artificial Intelligence Yichun HePhD Candidate, Harvard UniversitySchool of Engineering and Applied SciencesThe Broad Institute of MIT and Harvard Abstract:The mammalian brain exhibits complex functions and behaviors, driven by diverse cell types distributed throughout its tissue. However, understanding the heterogeneity of cell types and neuronal functions across the...

Engineering the retinal microenvironment to improve donor neuron integration post-transplantation Jonathan Soucy, PhDPostdoctoral Research FellowOphthalmology Department at Harvard Medical SchoolSchepens Eye Research Institute of Mass. Eye and Ear Abstract:Neuron transplantation is an exciting solution for replacing retinal ganglion cells (RGCs) lost in glaucoma and other optic neuropathies. However, one significant barrier to successful donor RGC...

Vascular Dysfunction in Disease: Engineering Mechanobiology Holds the Solution Shailaja Seetharaman, PhDPostdoctoral ResearcherJames Franck Institute and Department of PhysicsUniversity of Chicago Abstract:Abnormalities in blood vessel and blood flow properties are key drivers of severe cardiovascular and cerebrovascular pathologies. The remarkable ability of the vasculature to sense and respond to mechanical and biochemical signals across multiple...

Harnessing Geometry and Topology in Machine Learning for Biomedical Discovery Dhananjay Bhaskar, PhDPostdoctoral Researcher, Yale UniversityYale - Boehringer Ingelheim FellowKavli Institute for Neuroscience FellowVisiting Scholar in Engineering, Brown University Abstract:Understanding the shape of data through geometry and topology offers a powerful perspective with the potential to drive breakthroughs in biomedical science and engineering. This talk...

Metabolic Adaptations of Drug-Tolerant Persister Cells Mehmet A Orman, PhDAssociate ProfessorChemical and Biomolecular Engineering DepartmentUniversity of Houston Abstract:My research focuses on understanding drug-tolerant phenotypes, particularly persister cells, in both prokaryotic and eukaryotic systems. Persister cells are temporarily tolerant to drugs and contribute significantly to disease recurrence. We investigate their molecular makeup, including metabolite profiles, RNA...