September 23
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12:00 PM
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1:00 PM
Engineered Inorganic Nanoparticles as Photoacoustic Theranostics for Cancer and Inflammatory Diseases
Taeho Kim, PhD
Assistant Professor, Department of Biomedical Engineering
Institute for Quantitative Health Science and Engineering
Michigan State University
Abstract:
Functional inorganic nanoparticles feature interesting optical, magnetic, plasmonic, and catalytic properties as well as effective (bio)molecular recognition. Nanoparticles with imaging capabilities can be used as sensitive diagnostics to detect disease initiation and progression and to track therapeutic intervention. Upon loading therapeutic payloads into the nanoscale matrix or exploiting the intrinsic nanoscale properties, ‘theranostic’ nanoparticles can improve treatment specificity to offer image-guided targeted therapy. Photoacoustic (PA) imaging is an emerging non-invasive technique that combines the high spatiotemporal resolution of ultrasound with the excellent spectral contrast of optics. The powerful PA imaging can overcome the drawbacks of conventional imaging modalities to improve over the therapeutic potential of nanomedicine. In this seminar, I will present recent efforts in my lab to develop novel translational nanotheranostic agents for cancer treatment or managing inflammation in tandem with PA imaging. I will also emphasize our recent work in theranostic nanomedicine in uterine disease.
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