October 28
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12:00 PM
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1:00 PM
Autonomous Multiscale Imaging for Studying Rare Biological Phenomena
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Kevin Dean, PhD
Assistant Professor
Cecil H. and Ida Green Department of Systems Biology
Lyda Hill Department of Bioinformatics
University of Texas Southwestern
Co-sponsored by Morgridge Institute for Research and the Center for Quantitative Cell Imaging
Abstract:
Investigating rare biological events, such as metastatic colonization, requires imaging systems capable of capturing these phenomena within large, multicellular contexts. To achieve this, the Dean lab is developing autonomous, multiscale light-sheet microscopes optimized for imaging chemically cleared and expanded tissues. At the heart of these systems is navigate, an open-source, Python-based control software tailored for intelligent light-sheet microscopy. Navigate offers a reconfigurable hardware interface and intuitive GUI, enabling complex imaging routines without requiring advanced programming skills. It supports multiple light-sheet modalities, integrates seamlessly with external analysis tools, and allows for real-time, decision-based imaging workflows. This platform’s robust and versatile design enhances the efficiency and reproducibility of biological imaging, providing a powerful tool for studying rare but significant biological processes in situ.
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