November 25
@
12:00 PM
–
1:00 PM
Optimizing Intracortical Microstimulation: Addressing Perceptual Fading through Inhibition, Metabolic Stress Reduction, and Gliomodulation
Takashi Kozai, PhD
Associate Professor
Department of Bioengineering
University of Pittsburgh
Abstract:
Intracortical microstimulation (ICMS) offers promising applications in neuroprosthetics by providing direct modulation of neural circuits. However, long-term ICMS effectiveness is limited by perceptual fading, a phenomenon where neural responses decrease with repeated stimulation. This seminar will examine strategies to counteract perceptual fading by addressing three critical elements: inhibitory modulation, metabolic stress reduction, and gliomodulation. Gliomodulation, encompassing astrocytes, microglia, and oligodendrocytes, plays an essential role in maintaining synaptic stability, managing inflammatory responses, and reducing network metabolic load. By facilitating axonal myelination and supporting energy efficiency, oligodendrocytes significantly lower metabolic stress, which is crucial for sustained neural activity during ICMS. Additionally, modulating inhibitory interneurons helps maintain excitatory balance, thereby preserving the fidelity of neural signals and reducing adaptation. We will discuss techniques to optimize ICMS protocols for balanced inhibitory activity, gliotransmission, and reduced metabolic demands. The seminar will outline experimental approaches for integrating these elements to achieve stable, durable neural responses and enhanced clinical viability of ICMS-based neuroprosthetics.
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