Sleep was on Nicolas Greaves and his groupmates’ to-do list. But, with motors to test, force calculations to crunch, prototype components to 3D print and more, the tasks kept stacking up. In the end, Greaves…
In an ideal world, after the CRISPR-Cas9 gene-editing tool enters a cell’s nucleus and cuts its targeted slice of DNA, it would disappear. “You don’t want the Cas9 protein to stick around too long,” says…
Yang Lu likes to say that searching the human genotype for a biomarker of a given disease is akin to trying to find a needle in a haystack. Or, more accurately, needles—the set of biomarker…
Chimeric antigen receptor (CAR) T cell therapy is transforming cancer care for patients with cancers of the blood, but has proven especially challenging to develop against solid tumors. Researchers at the Morgridge Institute and UW–Madison…
When doctors diagnose ovarian cancer at an early stage, patients have a five-year survival rate of better than 90%, according to the American Cancer Society. That rate plummets as the disease progresses to further stages….
To determine which genes are responsible for—or act as biomarkers of—a given disease, researchers must work their way through thousands upon thousands of genes, using previous scientific studies as their guide. After identifying a candidate…
Dhananjay Bhaskar can’t hide his enthusiasm on the other end of the video call as he carries his laptop down the hallways of Yale University’s new Wu Tsai Institute building. He stops in front of…
David Dean has stories. Of walking into a lab at the Cleveland Natural History Museum as an undergraduate student and seeing the bones of the famous “Lucy” Australopithecus fossil skeleton laid out on a table….
As he got deeper and deeper into biomedical research over the past decade and a half, Duc-Huy Nguyen came to two conclusions: Given the genetic similarities between mice and humans, it’s understandable why the former…
Maggie Eggleston enjoys horseback riding, watching movies and reading mysteries—a fairly typical set of interests for a 16-year-old girl. But Maggie’s lived experience is anything but typical. Three years ago,…