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Aarushi Bhargava

Aarushi Bhargava

Assistant Professor

Aarushi Bhargava leads the Sonic Interactions with Materials (SonIMate) Mechanics group. The group focuses on understanding the mechanics of ultrasound interaction with soft materials (synthetic and biological), and leverages that understanding for developing innovative solutions in non-invasive therapy and targeted drug delivery. Physical concepts from different fields, such as wave physics, material mechanics, and fluid dynamics, are applied to design technologies for various biomedical applications. A variety of tools, including analytical methods, computational modeling, and experiments (in vitro and in vivo), are used to implement these technologies.

Department

Biomedical Engineering

Contact

2160, Engineering Centers Building
1550 Engineering Dr
Madison, WI

  • PhD 2020, Virginia Tech
  • BS 2015, Birla Institute of Technology and Science
  • MS 2015, Birla Institute of Technology and Science

  • Acoustic cavitation
  • biomedical ultrasound
  • biomechanics
  • acoustic-structure interaction
  • programmable smart and soft materials
  • microdevices
  • tissue ablation
  • drug delivery

  • 2022 Max Planck Institute for Intelligent Systems, Humboldt Postdoctoral Fellow
  • 2020 Acoustic Society of America meeting, ASA participation grant
  • 2020 Acoustic Society of America meeting, Early career support award
  • 2019 Virginia Tech, Amir Chand and Dewki Bai Batra fellowship
  • 2019 Virginia Tech, Graduate student symposium research award (bronze medal)
  • 2018 Virginia Tech, Liviu Librescu Fellowship
  • 26th SPIE Annual International Symposium on Smart Structures and Materials & Nondestructive Evaluation and Health Monitoring, Best Student Paper Award - Honorable Mention
  • 10th ASME Conf. on Smart Materials, Adaptive Structures and Intelligent Systems, Best Student Paper Award

  • Kim, D. W., Wrede, P., Estrada, H., Yildiz, E., Lazovic, J., Bhargava, A., Razansky, D., & Sitti, M. (2024). Hierarchical Nanostructures as Acoustically Manipulatable Multifunctional Agents in Dynamic Fluid Flow. Advanced Materials, 36(50), 2404514.
  • Han, M., Yildiz, E., Bozuyuk, U., Aydin, A., Yu, Y., Bhargava, A., Karaz, S., & Sitti, M. (2024). Janus microparticles-based targeted and spatially-controlled piezoelectric neural stimulation via low-intensity focused ultrasound. Nature Communications, 15(1), 2013.
  • Hendley, S. A., Bhargava, A., Holland, C. K., Wool, G. D., Ahmed, O., Paul, J. D., & Bader, K. B. (2022). (More than) doubling down: Effective fibrinolysis at a reduced rt-PA dose for catheter-directed thrombolysis combined with histotripsy. Plos one, 17(1), e0261567.
  • Bhargava, A., Huang, S., McPherson, D. D., & Bader, K. B. (2022). Assessment of bubble activity generated by histotripsy combined with echogenic liposomes. Physics in Medicine & Biology, 67(21), 215015.
  • Toledo-Urena, J., Centner, C., Bhargava, A., & Bader, K. B. (2022). The role of histotripsy pulsing rate on clot degradation when combined with thrombolytic drug. The Journal of the Acoustical Society of America, 152(4_Supplement), A247--A247.
  • Centner, C., Bhargava, A., Huang, S., McPherson, D. D., & Bader, K. B. (2022). Thrombolytic efficacy of histotripsy combined with thrombolytic-loaded echogenic liposomes. The Journal of the Acoustical Society of America, 152(4_Supplement), A247--A247.
  • Bhargava, A., & Shahab, S. (2021). Acoustic-electroelastic modeling of piezoelectric disks in high-intensity focused ultrasound power transfer systems. Journal of Intelligent Material Systems and Structures, 32(11), 1215--1233.
  • Bhargava, A., Hendley, S. A., & Bader, K. B. (2021). An In vitro System to Gauge the Thrombolytic Efficacy of Histotripsy and a Lytic Drug. Journal of visualized experiments: JoVE(172), 10--3791.
  • Hendley, S. A., Dimov, A., Bhargava, A., Snoddy, E., Mansour, D., Afifi, R. O., Wool, G. D., Zha, Y., Sammet, S., Lu, Z. F., & others, (2021). Assessment of histological characteristics, imaging markers, and rt-PA susceptibility of ex vivo venous thrombi. Scientific Reports, 11(1), 22805.
  • Bhargava, A., Huang, S., McPherson, D. D., & Bader, K. B. (2021). Cavitation dynamics of histotripsy bubble cloud nucleated from echogenic liposomes. The Journal of the Acoustical Society of America, 150(4_Supplement), A29--A29.

  • B M E 315 - Biomechanics (Spring 2025)
  • B M E 399 - Independent Study (Spring 2025)
  • B M E 890 - Pre-dissertation Research (Spring 2025)
  • B M E 200 - Biomedical Engineering Design (Fall 2024)
  • B M E 300 - Biomedical Engineering Design and Leadership (Fall 2024)