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Paul Campagnola

Paul Campagnola

Peter Tong Department Chair, Biomedical Engineering
Professor

Our lab focuses on studying alterations of the extracellular matrix (ECM) in cancer as well as in connective tissue disorders. To this end, we use Second Harmonic Generation imaging microscopy for imaging structural aspects of tissues, where the approaches will ultimately be implemented as clinical diagnostics. We also use 3D nano/microfabrication approaches to create biomimetic models of the ECM to study signaling pathways associated with cancer and also to provide insight into the design of tissue engineering scaffolds.

Department

Biomedical Engineering

Contact

Engineering Centers Building
1550 Engineering Dr
Madison, WI

  • PhD 1992, Yale University
  • BS 1986, Colgate University

  • biophotonics
  • tissue imaging
  • breast and ovarian cancer
  • connective tissue disorders
  • nanofabrication
  • cancer cell biology
  • tissue engineering

  • 2021 Univ. of Wisconsin-Madison, Big 10+ alliance academic leadership program Fellow
  • 2020 College of Engineering, Univ. of Wisconsin-Madison, Peter Tong Department Chair, Biomedical Engineering
  • 2020 AIMBE, Fellow
  • 2020 Univ. of Wisconsin-Madison, Kellett Faculty Fellow
  • 2018 Optical Society of America, Fellow
  • 2014 Univ. of Wisconsin-Madison, Vilas Associate
  • 2007 National Taiwan University, Visiting Scholar
  • 1992 University of Colorado, JILA Fellowship
  • 1986 Yale University, Kent Fellow

  • Shelton, E. M., & Campagnola, P. (2024). A Combined Theoretical and Computational Model for Predicting the SHG Spatial Emission Pattern Due to the Collagen Fibril Assembly. In Microscopy Histopathology and Analytics (pp. MW3A–2).
  • Campagnola, P., & Alkmin, S. (2024). High-resolution imaging and biological consequences of collagen morphology and stiffness alterations in ovarian cancer. In Optical Elastography and Tissue Biomechanics XI (p. PC1284405).
  • Campagnola, P., Roblyer, D. M., & Walsh, A. J. (2024). Multiscale Imaging and Spectroscopy V. In Proc. of SPIE Vol (pp. 1282701–1).
  • Campagnola, P., Champer, M., Shelton, E., & Singh, V. (2024). SHG imaging and analysis of collagen fiber/fibril architecture in human ovarian cancer using machine learning and emission directionality. In Multiphoton Microscopy in the Biomedical Sciences XXIV (p. PC128470L).
  • Gant, K. L., Patankar, M. S., & Campagnola, P. (2024). A Perspective Review: Analyzing Collagen Alterations in Ovarian Cancer by High-Resolution Optical Microscopy. Cancers, 16(8), 1560.
  • Champer, M., Singh, V., & Campagnola, P. (2023). Artificial image tuning using a generative adversarial network on collagen images from second harmonic generation microscopy. In Multiscale Imaging and Spectroscopy IV (p. PC1236309).
  • Campagnola, P., Atry, F., Alkmin, S., Singh, V., Wen, B. L., Campbell, K. R., Patankar, M., Champer, M., & Lien, C. (2023). High-resolution imaging and modeling of collagen architecture alterations in high-grade serous ovarian cancer. In Optical Methods for Inspection, Characterization, and Imaging of Biomaterials VI (p. PC126220O).
  • Campagnola, P., Sandbo, N., James, D. S., Shelton, E., & Jones, M. (2023). Multiscale SHG/THG analysis of collagen architecture alterations in human idiopathic pulmonary fibrosis tissues and in vitro models (Conference Presentation). In Multiphoton Microscopy in the Biomedical Sciences XXIII (p. PC123840O).
  • Nair, A., Lin, C., Hsu, F., Wong, T., Chuang, S., Lin, Y., Chen, C., Campagnola, P., Lien, C., & Chen, S. (2023). Categorization of collagen type I and II blend hydrogel using multipolarization SHG imaging with ResNet regression. Scientific reports, 13(1), 19534.
  • Mora, E. M., Champer, M. I., Huang, W., Campagnola, P., & Grimes, M. D. (2023). Collagen is More Abundant and Structurally Altered in Lichen Sclerosus. Urology, 173, 192--197.

  • B M E 399 - Independent Study (Spring 2025)
  • B M E 402 - Biomedical Engineering Capstone Design II (Spring 2025)
  • B M E 799 - Advanced Independent Study (Spring 2025)
  • B M E 890 - Pre-dissertation Research (Spring 2025)
  • B M E 990 - Research and Thesis (Spring 2025)
  • PHYSICS 990 - Research (Spring 2025)
  • B M E 399 - Independent Study (Fall 2024)
  • B M E 400 - Capstone Design Course in Biomedical Engineering (Fall 2024)
  • B M E 890 - Pre-dissertation Research (Fall 2024)
  • B M E 990 - Research and Thesis (Fall 2024)
  • PHYSICS 990 - Research (Fall 2024)
  • B M E 990 - Research and Thesis (Summer 2024)
  • PHYSICS 990 - Research (Summer 2024)
  • B M E 399 - Independent Study (Spring 2024)
  • B M E 402 - Biomedical Engineering Capstone Design II (Spring 2024)
  • B M E 799 - Advanced Independent Study (Spring 2024)
  • B M E 990 - Research and Thesis (Spring 2024)
  • PHYSICS 990 - Research (Spring 2024)
  • B M E 399 - Independent Study (Fall 2023)
  • B M E 400 - Capstone Design Course in Biomedical Engineering (Fall 2023)
  • B M E 790 - Master's Research and Thesis (Fall 2023)
  • B M E 799 - Advanced Independent Study (Fall 2023)
  • B M E 990 - Research and Thesis (Fall 2023)
  • PHYSICS 990 - Research (Fall 2023)
  • B M E 990 - Research and Thesis (Summer 2023)
  • PHYSICS 990 - Research (Summer 2023)