February 2
@
12:00 PM
–
1:00 PM
From Engineering Predictive Human Tissue Platforms to Advancing the Impact of Wisconsin Biomedical Engineering
Salman R. Khetani, PhD
Professor
Associate Department Head
Acting Associate Dean for Graduate Studies
Department of Biomedical Engineering
University of Illinois Chicago
Abstract:
The convergence of patient-specific human cell sources, microengineering, and data science is accelerating the adoption of New Approach Methodologies (NAMs) that reduce reliance on animal studies. Against this backdrop, my lab develops highly functional, long-lasting in vitro human tissue platforms for drug metabolism and toxicity testing, disease modeling, and regenerative medicine. We emphasize reproducibility, scalability, and ease of use to enable broad adoption by end users. We leverage these systems to uncover cellular and molecular mechanisms that drive major human diseases and to inform more effective therapeutics, including metabolic dysfunction–associated steatotic liver disease, alcohol-associated liver disease, hepatitis B viral infection, inflammatory bowel disease, lung fibrosis, and atrial fibrillation. We are further extending our platforms into reproductive and developmental health, where clinical guidance is often limited, and advancing vascularized, implantable human liver tissue surrogates as a bridge-to-transplantation strategy for patients with end-stage organ failure.
Print PDF