February 16
@
12:00 PM
–
1:00 PM
Aortic biomechanics and mechanobiology and a vision for the future of UW BME
Jessica Wagenseil, DSc
Professor
Department of Mechanical Engineering and Materials Science
Vice Dean for Faculty Advancement
McKelvey School of Engineering
Washington University
Abstract:
The extracellular matrix protein, elastin, provides reversible extensibility to the aorta that is critical for proper function of the cardiovascular system. Elastin is deposited during late embryonic and early postnatal growth, at the same time that blood pressure and flow are increasing. This relationship suggests that mechanobiological signals for elastin deposition are linked to hemodynamic forces. I will discuss how reduced or absent elastin affects aortic mechanics, cardiovascular hemodynamics, aortic wall development, and gene expression in genetically modified mouse models. I will introduce mathematical models that we use to better understand the cause and effect relationships between elastin amounts and cardiovascular hemodynamics. I will show preliminary data on how reduced elastin may affect smooth muscle cell mechanosensing leading to phenotypic changes associated with disease. The combination of experimental work and mathematical modeling will advance our understanding of how the aortic wall is constructed to provide appropriate extensibility for normal cardiovascular function and uncover novel treatment options for cardiovascular diseases associated with elastin defects. I will also discuss my vision to promote and support high-impact research initiatives, development efforts, and the instructional mission in the UW BME department.
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