September 15
@
12:00 PM
–
1:00 PM
Electrical Manipulation of Biological Cells: Models and Applications
Allen Garner, PhD, PE
Professor, Graduate Program Chair
School of Nuclear Engineering
Purdue University
Electric waveforms, including electric pulses (EPs) and alternating current (AC) fields, such as radiofrequency and high-power microwaves, can induce deleterious or beneficial effects that require additional characterization. We combine thermal models with the Smoluchowski equation to assess the interactions of EP and AC waveforms with biological cells. We further develop a computationally efficient model based on the asymptotic Smoluchowski to screen biological response over seven orders of magnitude of pulse duration with excellent agreement between simulated electroporation and experimental observations. Applications in microorganism inactivation, natural products for cancer therapy, platelet activation, and stem cell stimulation will be discussed.
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