April 22
@
12:00 PM
–
1:00 PM
Developing retinal laser speckle contrast imaging for the diagnosis of ocular and systemic disease
Dan Lipinski, PhD
Associate Professor of Ophthalmology & Visual Sciences, Cell Biology, Neurobiology and Anatomy
Research Director of the Department of Ophthalmology and Visual Sciences
Medical College of Wisconsin
Abstract:
Laser speckle contrast imaging (LSCI) is a powerful modality that is capable of rapidly and non-invasively generating wide-field, dye free maps of vascular perfusion and has been employed extensively in neuroscience and diabetes research for visualizing cortical and dermal blood flow in response to injury and disease. In this seminar we explore the principles underlying LSCI, discuss the challenges of employing LSCI as a tool for studying ocular disease in both animal models and human subjects, and highlight the potential for LSCI to be employed as a diagnostic tool for the early detection of pre-symptomatic vascular alterations in neurodegenerative disease, including Alzheimer’s.
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