October 27
@
12:00 PM
–
1:00 PM
Predicting Thrombus Formation, Deformation, and Embolization: A Look at Devices, Stroke, and Deep Vein Thrombosis
Keefe Manning, PhD
Professor of Biomedical Engineering and Surgery
Department of Biomedical Engineering
Pennsylvania State University
Abstract:
Thrombosis remains a significant clinical issue manifesting in heart attacks and strokes but also challenges the success of cardiovascular devices. Given the complex process associated with thrombosis, developing accurate computational models is difficult as validation needs to occur over a range of flow and surface interactions and at different temporal and spatial scales. Thrombi are particularly interesting because of their inherent heterogeneity. Leveraging canonical experiments that acquire a breadth of data will be crucial to validate any computational model, but do these experiments accurately represent how thrombi form, deform, and embolize in the context of devices, stroke, and deep vein thrombosis? This presentation will cover the development and experimental validation of our computational models in these areas and the complications posed with blood experiments.
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