Faculty Spotlight: Duc-Huy T. Nguyen

Assistant Professor Duc-Huy T. Nguyen joined the department in Fall 2025.

Research Focus
My lab integrates engineering approaches such as tissue fabrication and 3D printing with biological expertise in stem cell, vascular, and liver biology to study how human tissues form and function. Since animal models often fail to capture human physiology, we develop in vitro 3D human tissue systems that better reflect human biology and disease. These models allow us to investigate the mechanisms that govern human tissue development, function, and dysfunction in health and disease.

Current Research
We are currently engineering vascular networks that support the growth and function of human liver tissue. We examine how blood vessels help maintain liver health, an organ responsible for more than 500 essential physiological functions, and how vascular signals contribute to diseases such as fatty liver and fibrosis. Another major focus of our lab is understanding genetic predisposition to fat accumulation and identifying therapeutic strategies for individuals at increased risk.

Research Impact on the Scientific Community
A major challenge in biomedical research is that discoveries made in animal models often fail to translate to human patients. By engineering physiologically relevant 3D human tissue models, our work helps bridge this gap. These systems provide a more accurate way to study how human organs function and respond to disease progression, strengthening the reliability of foundational discoveries and accelerating the path toward effective treatments and clinical interventions.

Research Impact for the People of Wisconsin
More than one-third of U.S. adults have fatty liver disease, and Wisconsin faces an even greater burden. With metabolic risk factors exceeding the national averages, the state carries a disproportionate number of undiagnosed cases. By identifying the molecular drivers of fat accumulation in the liver, our lab aims to advance therapeutic strategies that directly benefit Wisconsinites and help reduce the state’s healthcare and economic strain.

Fun Fact About Yourself
Outside of work, I am an avid dog trainer and enjoy staying active. My partner and I often take our puppies on hiking and kayaking trips, and we love exploring the many accessible trails and lakes Wisconsin has to offer.